ID A0A0V1A1Y6_9BILA Unreviewed; 2041 AA.
AC A0A0V1A1Y6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=T12_13994 {ECO:0000313|EMBL:KRY18313.1};
OS Trichinella patagoniensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=990121 {ECO:0000313|EMBL:KRY18313.1, ECO:0000313|Proteomes:UP000054783};
RN [1] {ECO:0000313|EMBL:KRY18313.1, ECO:0000313|Proteomes:UP000054783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS2496 {ECO:0000313|EMBL:KRY18313.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY18313.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDQ01000048; KRY18313.1; -; Genomic_DNA.
DR Proteomes; UP000054783; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.20.25.10; -; 2.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR019761; DNA-dir_RNA_pol-M_15_CS.
DR InterPro; IPR001529; DNA-dir_RNA_pol_M/15kDasu.
DR InterPro; IPR001661; Glyco_hydro_37.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF12; TREHALASE; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF02150; RNA_POL_M_15KD; 1.
DR Pfam; PF01204; Trehalase; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SMART; SM00661; RPOL9; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 2.
DR PROSITE; PS01030; RNA_POL_M_15KD; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|RuleBase:RU361180};
KW Reference proteome {ECO:0000313|Proteomes:UP000054783}.
FT DOMAIN 488..542
FT /note="DNA-directed RNA polymerase M/15kDa subunit"
FT /evidence="ECO:0000259|SMART:SM00661"
FT REGION 1174..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1708..1745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..2041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1728..1745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2011
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2041
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2041 AA; 234921 MW; FD947D562C300656 CRC64;
MWTFSEHTYY EIKKHFKFAG YFTDFRFNVE PGLAWFARRN IRFASEIKKM PQHSILMFRL
FCLFSLELLR SVMGDKPVTP QGSFFRVYSQ DRQYRDLAMT GDKASKLACG PTKRAFDHDV
VWATDHPAAG PLLDELVDAM VYAKCDVNVP DDANMSVMMT LRAVNMEKPQ IKQDAASGMR
SSALDPERMK SVLQAMQKSG AQGVSQDNID RALQLIELAL KEKRAISIHE MEEVLRLVEF
NVFIGADGLK QMFERLVNDK TLTEGQANGI LQPLLAKAAS KADGKLPMQE IIFFTTLPTL
GWCMSTPTNL HYLFKVMQRS GAQREAKDNI DRALRMIELV VKEKREISIQ EMEEILCMVE
SNVFIGIDGL NQMFEYLVNK KTLTDAEAIG ILPSLLAKAA AKAQKKIPLQ NVREALKNFM
TVKEYFFFIF IFYSIYQESS LSFQNYRTNI KSQCNYSTTV RLYSVEQLNK LKVEQKAHVD
TLKHPGIIFC PECNNILYPK EDKSRRCLLY ACRNCSYVTD DIVSVCVYTN KLRREIDELA
QVNVDVIYDP TLPKTDDHSC PLCNNSEAVF FQSQNTKAEP NNKVSLDKMM YYVVSLLSQI
YCQGPILDAV QTAHLFPDSK YFVDMALKKD PITTLQNFIS LGDRVKDKAV LRAFVDEHFD
PPGTELETCF PEDWKPSPKS FNVIKDYEFR RWAVALNRIW KELCRRVKSK VFEHQELYSL
LYVPNPFIIP GGRFREFYYW DTFWIAKGLI ASEMFTTLKG MIRNLGYMVE NHGFVPNGGR
VYYLFRSQPP LLIPMVYDYY LATGDIDFLQ EMLPLLEQEY GFWLLHRGMT FGDDSNNYMK
LFQYKAEMKM PRPESYREDL ELVQNLTDDH AREFVWAQIV SGAETGWDFS SRWFSHTGPE
AFTLRSIRTW SIIPVDLNAF MCMNTKLLAN LYEMAGNVTK VLLYQARFEQ AKAAMKQIHW
NEQDGIWYDY DLETKRHVDV YYISNVLPLY AKCYDDEDVP SRVYNYLKTV GALNSTRGVP
TSFIQSDQQW DSANAWPPMV HMLLEGLRTS GDPEIIEVAK ELAIQWLRSS YDAFLKTNSM
FEKYNVSSTA GEMPFGSGGE YEVQTGFGWT NGVILDLLVK YGDVITAQDA TTGTINYWKY
AAYVVFVMKS ELKQDEHALK EEILGFMNKI GLKKDGKNKN SSRISTPVRR ETKRTFNNNG
KLIFSGDSAW NNNSSGSKNK QQQQQQQQQR ANKLLPTKIK TEDLNEHPVS ESSVQRWFDA
KFTDVVGSQP LSEHSLMKME AYAKQLFQNQ AVNYEKETMN KKNNSNQLRW MNSVASGGTL
SDRVAALGML VQQSPLHNLK HLDTLLNKVT KKNRHEALIA ADVAKDLFIE ELLPDRKLIP
FKSRPYVEIE NTKGQSKAAV DRKLLLWQFE SELKMKYQQF VHALEQLCHD TVEAVRLKGC
ILLVDLLIAK AEQEQFILSS LVNKLGDQSV KVATQVVKLI GRLFLAHPNM KVVVVDELEK
LIYRKNITPC AQFYAICALL KVPLNRNNDE DLACKILNVY FDLFKIVIQS DVENQRLLRH
LLLGTNVAFS YSKGKFDRIS EEVDTLYKIA ATSSLYINLQ ALALLFQVLD VKAEISDRFY
RSLYRTMLVP ELLSSSRCHA MFFHLLFKSM SQDFSDQRIR AFVKRLLQVC LMAPAPFICA
ALLVISQALH GRLKRFVAIA DQWVEDDHEE QEKVDDEEEK EIGNGKKKQT STESNNTNDN
KQNANNIYGN VYGSREYNIA GREPLHANAD RESLVELLLL RNHYHPTVAV FAENLLKGNH
INYSGNPLDD FSLMHFLDRF VFKNPKKSIS ENVEEKNTEK RGYKRKIYDP WSLRSLPVTS
SAYALHHKSH VPPDEKYLHS FMTNANVKRA EEQLSEESDD ESVNSEEFEI LLGKKLDFKK
QNFWSTFLGK FEIGNKRRRR RSKRSEDSDD SDNPSDSSGD ESDFEAGRSK LDDTAALTGD
NDDSTDGGVL DDDDDDATTA AEEFGEILEN DDEEDEKKKH DRKRKAYKKF QKVRQRRRRR
R
//
