ID A0A0V1CHA3_TRIBR Unreviewed; 569 AA.
AC A0A0V1CHA3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 30 {ECO:0000256|ARBA:ARBA00019664};
DE AltName: Full=Mediator complex subunit 30 {ECO:0000256|ARBA:ARBA00031981};
DE Flags: Fragment;
GN ORFNames=T03_16873 {ECO:0000313|EMBL:KRY48662.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY48662.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY48662.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY48662.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 30 family.
CC {ECO:0000256|ARBA:ARBA00010606}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY48662.1}.
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DR EMBL; JYDI01000200; KRY48662.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1CHA3; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR018790; DUF2358.
DR InterPro; IPR021019; Mediator_Med30_met.
DR PANTHER; PTHR31094; RIKEN CDNA 2310061I04 GENE; 1.
DR PANTHER; PTHR31094:SF2; RIKEN CDNA 2310061I04 GENE; 1.
DR Pfam; PF10184; DUF2358; 1.
DR Pfam; PF11315; Med30; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 23..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..207
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 59..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRY48662.1"
SQ SEQUENCE 569 AA; 65374 MW; FDD94FE596A466F7 CRC64;
LKINYAFKMS QQNQNSFIQT FPLPPRPLNS NGNNLDANYG YPQGIGQSSV SSPIQSLVNS
FGSRREVPSP SPASVSESTN VAPGKTTQAD ESQQEHHAER EAWSAQGSKA FNVNPFFAFS
MSQILQSNDN SGPLALCIIG RDFTREVINR TCDICGALKS LQLPTAPEAV KQHQDKLQRI
NESLKQVNII LERLEAIDRK IDNFRKELLP ADAEDHLKVL IFLNVCSIVC NYQFFQDLVT
YDGKNEWLRK LTEERKSREV FTQTKQQYDE VKKELEKHAP SCSARSFNFC SLKLAQFDPR
EFGLRLKPYI ANSDDIHIPF RRPFFSCTNS LIYPDYNSYF IPIIRNLSSK KSKNDSVSES
LVKRRVSFNF SAVYSQVVNQ CSSTEKSPTH YFERGKPNWD QLQHVIYRLS ETVPTFFLRR
LDYTFYSDDV LFLNRICGSE VKGLRNYWLH LATLSVLSRI PCPYIEMKIL NCMPIVEEGS
VHLRWRVLYL TVPEFLYVVV RERSADIETL RRNARWFDGF SYFYVGSDGL VYKHVADRVM
RDPEEIAANS KRVGLLNRLL GSSARSPVF
//
