ID A0A0V1CJ05_TRIBR Unreviewed; 1291 AA.
AC A0A0V1CJ05;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE RecName: Full=Methionine--tRNA ligase, mitochondrial {ECO:0000256|ARBA:ARBA00026124};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE AltName: Full=Mitochondrial methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030331};
GN ORFNames=T03_14007 {ECO:0000313|EMBL:KRY49006.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY49006.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY49006.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY49006.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY49006.1}.
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DR EMBL; JYDI01000189; KRY49006.1; -; Genomic_DNA.
DR STRING; 45882.A0A0V1CJ05; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd07061; HP_HAP_like; 1.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KRY49006.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653}.
FT DOMAIN 57..157
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
FT DOMAIN 269..625
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
SQ SEQUENCE 1291 AA; 147567 MW; 0BAAE8C4DB1F6ED5 CRC64;
MIGKPSNFVM KRLSEELKCP TSSVMGRLAS VMYLRKFKEI SSNVVNILNP SADDRILEVG
FGLGYGLFEA FKKVERGNGV VFGSERSQYM VKRARKIFAL EIHYGRLEVD LSLASHLPYL
NSSIDCIFHN DCFYYWPSVK NALLELKRVL KPGGRMLTSM SIERVKEWSS RGLLQPSYCI
DPLDYILHLE NTGFVDIKFE YHSSAGVQFQ TVVALKPPVE EDRGVNLDVE EKNFQQEILE
FEKLRLTAFI VNILQSSVVM NLLHRGISYF VTAPIYYANS GPHLGHLYSS LIADAAHRWF
KLKNPHQLTL FSSGTDEHGS KVENAALKAE KNVDVYCSEI SSAYRELFSK FGIETTDFIR
TVEARHHQSV QQFWEVLRKN NFIYKGKYSG WYCSADECFY NESDLCDDET KSCKITTAGH
TVEWVVEENY LFKLSEFLPE IQHWLQTSDV IQPSQYLPFV INQLKQLSDV SISRDRQRLS
WGIPVPDDCS QTIYVWFDAL VNYLTVAGYP GQLCRWPPDC HIIGKDILKF HAILWPAMLL
AANFPLPKQI FCHGHWLSDG VKMSKSLGNV VDPTLEAQKL TCEGLRYFLL RQGVPTSDGN
YSTPLAISVL NDELANSIGN LINRTTSSRV LRGDRFTDFD DSVINGPSIR QGPDLMTDLD
NLPSIVGQQY DKMQFSNGIN SIVTVVKKAN AFVQHFSPWH LAKDKNANSL LDTVLHLAHQ
TLRTCGILLK PVVPNIADEM LNRLSVSSDE SNYSDCAKAA SKSRYFSGKP LNHQKDLILF
PRISRFLENC QLSINREMMQ DAFHSCSASC MELIVGELIW RHGHRTPIYL IPSDVENNAS
TWNIGLGELT KLGMRQCYEL GQMLGKRYIE QYPLFKSSIL NEIYIRSSDT NRTLMSAASV
MAGFVASDSY GNYGNYTLPN FVRSPAGWNP LPIHTVDYGT DNLLNMRYHW NKTANLFRKN
FIEYDRFIKQ NPDNGAKLAY VANKSGFNNT LVKNMWILAD VVKIEKEGSA EDWHSDQHNL
PDWVTDEIYD WIQHTFKHWC KLVYQPDLLI QITAGDLIFE IVDRIHQKQL SIKQSQNTNS
WIERIKFYSY SGHDINLLFL LYILGQYDNV ATVEYEGYAS CIVFEAWLTE ENETEIKVFL
RRGPNSTEFQ PIQVVGCPPI PSGCPLATFE NRTRKFFPKP NKVDVDCCSS ASSFSIFDSL
FQINIFRRYD RFFFCLSFFA RCSTLPSTCD FHVNFLRPSR GSTPRLPMAL PLRPMLMPTL
LPLKDKKLCA LSMGDHFHYL WTSVAFDVSR S
//
