ID A0A0V1CS92_TRIBR Unreviewed; 756 AA.
AC A0A0V1CS92;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Phenylalanine--tRNA ligase alpha subunit {ECO:0000256|ARBA:ARBA00015409};
DE EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
DE Flags: Fragment;
GN Name=farsa-b {ECO:0000313|EMBL:KRY52038.1};
GN ORFNames=T03_17420 {ECO:0000313|EMBL:KRY52038.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY52038.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY52038.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY52038.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Phe-tRNA synthetase alpha subunit type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00006703}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY52038.1}.
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DR EMBL; JYDI01000112; KRY52038.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1CS92; -.
DR STRING; 45882.A0A0V1CS92; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00496; PheRS_alpha_core; 1.
DR Gene3D; 1.10.10.2320; -; 1.
DR Gene3D; 1.10.10.2330; -; 1.
DR Gene3D; 3.30.1370.240; -; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR InterPro; IPR040724; PheRS_DBD1.
DR InterPro; IPR040586; PheRS_DBD2.
DR InterPro; IPR040725; PheRS_DBD3.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00468; pheS; 1.
DR PANTHER; PTHR11538:SF40; PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF18552; PheRS_DBD1; 1.
DR Pfam; PF18554; PheRS_DBD2; 1.
DR Pfam; PF18553; PheRS_DBD3; 1.
DR Pfam; PF01409; tRNA-synt_2d; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:KRY52038.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653}.
FT DOMAIN 227..498
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT REGION 721..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 756
FT /evidence="ECO:0000313|EMBL:KRY52038.1"
SQ SEQUENCE 756 AA; 86283 MW; 095C384D2A86E349 CRC64;
MEKNLADAVL VLLSQKSPID SDEIARHLNV SHQHIVGVIK SIEAMDHVIK TEQHSRKQWE
LTEEGKEIIK NGSHEAILWQ HVPNDGIIMD DLMRTVPNAK VGFNKAMSLG WIRLDKTGPK
PLVLRKVETI DDAVHDCLNK INSLNFDDVS AQNKSDLKKR RLINEIVIKT FRVFRDEKFT
TSLVKEETDL TVDLLTDNLW KEKKFKPYNF NAFGVVPVRG YLHPLMKVRT EFRQIFLEMG
FTEMPTQRYV ESSFWNFDAL FQPQQHPARD EQDTFFISKP MCTKNLPSEY VKRVEKVHSV
GDYGSSGYGY EWKIEEAEKN VLRTHTTASS IRMLYEIAKK PFKPVRYFSI DRVFRNESLD
ATHLAEFHQV EGLIAGENLS LGHLMGILQE FYKRLGIEKL RFKPAYNPYT EPSMEIFSYH
SSLKKWVEIG NSGMFRPEVL LPLGLAENVT VIAPTMIKYG INNIRDLIGP RHVCRVKMEI
GLKGLTLITT EQGCTGVPFA RALAKKALLE KSYSKILVVT NLSDSVSVWQ KIAPDSHEII
HDLPIVEENF SNAEYQEAML NLLLENKSQG VDRRNLIIFE NFSSSMLLMG TGGAVRFVHK
LTSQHPCLVI GCGSGTTVDE NLASFACTIY TLRLSSCGKV VIAVKCKSPP GRNLWNFQIT
DQFDFDHVQL YNEKQQNGPD NWPLVDSSNR LEVPASLERL VGFRLSLNEQ EMADKRNLTL
PYEKSGESEK SQARIIYYAE KDDDIDEDDP DSDLNI
//
