ID A0A0V1DIB9_TRIBR Unreviewed; 1154 AA.
AC A0A0V1DIB9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=Insulin receptor substrate 1 {ECO:0000256|ARBA:ARBA00015710};
DE AltName: Full=Protein chico {ECO:0000256|ARBA:ARBA00033282};
GN Name=irs2-b {ECO:0000313|EMBL:KRY60755.1};
GN ORFNames=T03_15420 {ECO:0000313|EMBL:KRY60755.1};
OS Trichinella britovi (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=45882 {ECO:0000313|EMBL:KRY60755.1, ECO:0000313|Proteomes:UP000054653};
RN [1] {ECO:0000313|EMBL:KRY60755.1, ECO:0000313|Proteomes:UP000054653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS120 {ECO:0000313|EMBL:KRY60755.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Bindings to phosphatidylinositol 3-kinase and SHP2.
CC {ECO:0000256|ARBA:ARBA00011440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY60755.1}.
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DR EMBL; JYDI01000004; KRY60755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1DIB9; -.
DR STRING; 45882.A0A0V1DIB9; -.
DR Proteomes; UP000054653; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF13; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF10269; Tmemb_185A; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022943};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oogenesis {ECO:0000256|ARBA:ARBA00022943};
KW Receptor {ECO:0000313|EMBL:KRY60755.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054653};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 995..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1033..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1124..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..116
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 233..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 129774 MW; E64754E034D88378 CRC64;
MDPLILFNES NVPDDIIKMG ILRKGKRARK RFFVLHQDSY NGPARLECFD NEKRYRCHAV
PKLSIPLKTC FNINKKVDSK LKFCIAMYTV DDYLLLGCEN ELDQDAWLHT LLEVLMNTKM
TGLSDDLRRA NFEYVWQVKV LKNRGLTEKV SKLAGLFRFC LNTCSVYFYK LNTDEEFFEF
PLVYISNYGH QGNLFFLRVG RSAVTGPGEL WMNTEDVVDA GSMHETMKII LEENHEQRQR
NMPIEPRGLR SDSQNSTRSN SISVTTTLPP EALMHSDLRS RAISENEKTL QKRCRRRMKI
KAIVDAIANP TKVLRSHLNY LQHRSHSGVS SKLEYLANLN CYSCGAPPSY SRSASHSPSV
LHNRSGYHGS ALATSPVIGL SNDSFGSISN SSDFDHFANG LRYSHRQHVG NPSLELISRS
TIVEESSGGS GTDCVPFCKT SKGILELNDE NSFRPARTLI THCVDVHSSP DCVETFRRMT
LDSGCVDPVS PRRDADAMSS SYSSEQISDY TPMAPGTTTA LSNAVTDSWR LEDIRPTIGP
DLVTAVPPLR AYSCGSKPTV RNYGSVKQPS WMRKLQHFSF NDERKRAHSF GNWKSAKLMS
LRKHSAQQGS DLGDSGGLRQ RSGSFGSDRS SGNSFKHQLP GRIFDSKFSS GSEDLVEIDF
GAFPYGRSNS GSFGSGDSLN RSRASSAGTA SIYRQSWSPK IEQISEQELS PSAKLIQDLI
FTRRCRPSLE RLAEYVPMSP PVANVNDDTV SGKGSTSMFG SAEGDHVDVN DVDEDDDETD
IMRVTREKKG LGSFRIRPVS DEITFSPDVD SSMDILQGVD RMMHSDISSF GRGNSAANAT
TVPLAAASLE QRLRFQRPMS SCKWSAAPRC SIRRRHSIGD PCGSIYEELK RRKKERFFHS
DMNFITKFPL SECCKSISLL KRIGRRSLPA DFSFQCFSRS PYSSHADKSR LKMVTTHNSN
NSNSGNTNTI NNAEDDYLML EPVSQFNLGT VVQRLFFLIS MSAIHRALFL WSCIMAFVII
AVMRLDGRIS WHWSVVFTPL WILDLVALFY TLLSCVRQVH LLRACSIGFA QIASDGYCKR
RNVSFLLVIL FKLCFLSLLS VKLEQQQHQH SAVGKFSTGE SIKFWHVMLP FWASVSIALA
EITYRLYHIY KCEM
//
