ID A0A0V1HUL9_9BILA Unreviewed; 4945 AA.
AC A0A0V1HUL9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dynein heavy chain, cytoplasmic {ECO:0000313|EMBL:KRZ14348.1};
GN Name=Dync1h1 {ECO:0000313|EMBL:KRZ14348.1};
GN ORFNames=T11_11646 {ECO:0000313|EMBL:KRZ14348.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ14348.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ14348.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ14348.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ14348.1}.
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DR EMBL; JYDP01000025; KRZ14348.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd05371; HSD10-like_SDR_c; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 3.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR PRINTS; PR00081; GDHRDH.
DR SMART; SM00382; AAA; 3.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024}.
FT DOMAIN 1895..2033
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2553..2703
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2895..3061
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1034..1090
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1281..1311
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3174..3233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3432..3487
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4945 AA; 567292 MW; 634512B9F7466F4F CRC64;
MVDNISEAIV DVSSPTVEIA QVELAEARVF SLFVRRIILL LLEDASGEPC GDAYATALDE
CLHRTDTVEV FRRFIADAQA PALLIERSCE RDSEETADAT EITEVVNYTV STEVHFSSPK
TNGLILIKRG AVLEADKPLI QQLLLFILAD ASPYETLHSY FSTTICPYFK SFVKESGGGD
NYRDTDKAAM SVEKKLIELE MGLLHLQQNI DIPDITLLIH PVVQSVIKQA AEENRRAKVS
DFGKLVDDST FLNQLQNGVT RWVREMQKVT KLDRDPSSGS ALQEITFWRN LERAVFNLLE
KRESPEVILT LEVLKHGKRF HATVSFDTDT GLKQALDTVT NYNVLMKDFP INDLLSAVEM
DRIRAAVASI FIHLRKIRTS RYPIQRCLRL IEAISRDLQI QMLKVLGMRR ILQISFDEFD
KVMTQAFEVF TCWDDEYEKL QALLRDLLKK KREEQLKLIW RIVPAHKKLQ FRLEEIRRFR
RHHEQLRAVI VRVFRLTSTL HGNENEHTFD ESPRMYDAAD TSVVEEVNVA YDFVKDIDCL
DLSKEGSDSW SSALKCYEER IDRVEGRIAT RLRDQLGSAK NANEMFRIFS QFNALFVRPH
IRGAIREYQT QLIERVKDDI EALHERFKKQ YSHSKACSTS SIYDIPPVSG FVIWAKQIER
QLALYLRRVE DVLGKGWENH IEGQALKTDG DIFRAKLNTQ PVFDEWVTKV QTRNLGLSGR
VFVVESVRRR NDSKASLRLR VNFLPDFITL AKEVRNFKNL SFRVPLAIVN KAHQVNQLYP
FAMSMIESVR TYELMTERLN EKENVAILLA GLVKEIHTQI AEGAGLVWES YKLDSYVQKF
SEMISHFQER VEELLHLEEQ IKIQLNLLDT CQYAAPAFQQ ILSNIQKSVD ALSLYQYSNL
DIWIKRLDEE IEQKLAIRLE EGIKSWIRAL KGEIDEENSS SEDLSAQSKF KVGGDPIIHS
FVHEIRITQQ VMYLSPCIEE IQVNLLQQLF SWEAIVTSQA RISSSCYHVE IERSSALTKY
RSLLAKLPHG IKYIEKAYAA IENLKLEVKD YVNEWLRYQA LWDLQADTLY DRLNTDLSKW
MKTLQELKEA RSTFDTSETR KQFGVIVVDF ARVQSKVSLK YDSWHKEILQ RFGTILGNEI
QNLYTVVNKA RTHLEQQSVD ISSTSEAVSF ITYVQNLKRN VLDWDDKVEC FREGQRILER
QRFQFPSNWL YSENFDGEWS AFSDILSRKS TAIQSQVNTL QAKIRQEATA VETRSADVVT
DWNSNKPIKG DQLPDVALQT LVVYEGKLSR LKEERDNISR AREALELQET SHTSVHGERL
KAAIEELNDL KQVWQALNPL YNELAEIKER LWLSVQPRKL RQNVDSLLNQ MKEMPANYRN
YDAYDHLKRL LQGYAKINFL IVELKSDALK SRHWKQVMSL LHVHWNLNEL TIGQIWACDL
QRYESSIKEI ILVAQGELAL EEFLKQLREF WQTYELELIN YQNKTKLIRG WDDLFNKLKE
HINSLNAMKL SPYYKEFEED CLVWEEKLNR ITALFDVWID VQRRWVYLEG IFSGSADIKT
LLPTETSKFQ SISSEFLGIM KKVSMSARVT EILNVPGIQR LLERLADMLN KIQKALGEYL
ERERSEFPRF YFVGDEDLLE IIGNSKNIPR LQKHFKKMFA GVACILFNED YTVIHGVASR
EGEEVNFLRS ISIKETPRVN EWLGLVEKEI QNTLAQLLVT CLQEFQKFKV HPIDADSYYN
WLDKFPLQVI TLAAQIAWSE DVELVLGKNA NLEPILKFVE NTLNLLADSV LHEHPPLRRK
KIEHLITEFV HKRCIMRYLM DCGVNSNQSF YWLKQMRFYL NTDEVDPQKK LTIRMANAQF
YYGFEYLGIQ EKLVQTPLTD RCFLTMTQAL ESRLGGSPFG PAGTGKTESV KALGNQLGRF
VLVFNCDENF DFQAVGRIFI GLCQVGAWGC FDEFNRLEER MLSAVSQQIQ AIQETLRLTQ
TKNDASVELL GKRVWVSPQM AIFITMNPGY AGRSNLPDNL KQLFRSLAMT QPDKRLIAEV
MLFSQGFRLA EKLASKIVPF FTLCSEQLSN QTHYDFGLRA LKYVLVKAGN VKRDHIQQLK
EQFQQVDRSF SEERFVLISF MSDVFPGIPH TKAEMKRLRE EIRKVCRERY LCYSEVEGEL
GYTWAEKVIQ LYQIVQLNHG LMMVGSSGTG KTKAWQVLLA ALGRVDGVDG AVHVIDPKAI
TKDALYGTLD PNTREWTDGL FTHILRKIID NVRGESTKRQ WIIFDGDVDP EWVENLNSVL
DDNKLLTLPN GERLALPQNV RIMFEVENLK YATLATVSRC GMVWFSADCV TEEMCFENYL
QKLRNVSLDA HENSGMPVSS LPVTQAQTNL TDQISPSLQV QRDIANILAP YLSCGGLVAR
CLEFAENQVE HIMEFSSCRA LSSFFSMISQ CIMKILLYNQ QHSDFPMAFD QMERYITRSL
LLSIVWSFVG DARAKYRDDM CEMIRSLTAI ALPAQENVSL IEFEVSIDGE WSSLHNRVPQ
VEVESHKVGA PDVVIPTIDT VLHEQLLYTW LADHKPLVLC GPPGSGKTMT LFSSLRSLPD
MEVVGLNFSS ASSPELLLKT FDHYCEYKRT PNGIVLSPVQ LGKWIVLFCD EINLPNYDKY
GTQRVISFLR QMVEHGGFYR SSDQAWVTVE RIQFVGACNP PTDPGRKPLS QRFLRHIPVV
YVDYPGELSL KQIYGTFNRA MLRMIPSLRS FAEPLTAAMV ELYLLSQDKF TPELQPHYVY
SPRELTRWVR GICEAIRPLE TLNVENLVKL WAHEALRLFQ DRLAEEDERR WTDEQIDLIA
AKHFPNVDAS VALRRPLLYS CWLTKDYLPV EREELRNFLQ ARLRIFYEEE LDVRLVFFDE
VLDHVLRIDR IFRQPQGHLL LIGVSGSGRA TLSRFVAWMN GLSVFQVKIH NKYSAENFDD
DLRLVLRRVG CKGEKLCFIM DESNLLDSSF LERINTLLAN GEVPGLFEGD EYTTLMSQIK
EASQHEGLIL DSSEELYRWF TQQVMRNLHV VFTMNPSSEG LKDRVSTSPA LFNRCVVNWF
GDWSKSALFQ VGRELTSNLD MDNTAYRSPD YFPYACDLVS RPPTYREAVV NAYVYVHETL
HQVVLQLTKR DHRTVLITPR HFLDFINHYV KLFHEKRKDL VDQQRHLNIG LSKIVETEQQ
VTELQKSLSL KSKELEEKNA LANEKLKQML SNRQEAENQK HMSEQIQSNL QQQLAEVAAK
KSDVMKQLAQ VEPAVIDAQN AVKSIKKQHL VEVRSMANPP GLVKLALESI CLLLGENCTE
WKLMRAVIVK DDFISRIVNF DTDSVTNIRR QHLGEIRYLS SPPATVKLAL EAVIFLFTGS
STLDWKSIRG YLLRDDFVSQ ILNFDTERIT EDIRQKMKTK YLDNPEYNYE KVNRASQACG
PMVKWATAQI NYAEMLHKVE PLRNELKKLE NDAEVNKRKV EDVNAVINQL EKSIASYKDE
YALLISEVQS IKADLIAVQT KVERSIQLLQ NLGSERQRWE QSSDTFKTQM ETIVGDVLLS
AAFISYAGYF DQQIRLSLFM NWSRHLDEAG IQFRPDISLV EYLANPDERL RWQQHALPVD
ELCVENAIML KRFTRYPLII DPSGQAIEFL MQEYGERKII RTSFMDDAFR KNLESALRFG
NSLLVQDVEC YDPILNPVLN YEVKRAGGRV LITVGDQDID LSPSFQIFLS TRDPTIQLTP
DICSRVTVIN FTVTRSSLQS QCLNHILKAE RPDIDSKRSD LMKLQGEFAL RLRHLETSLL
QALNDVKGRI LDDDSIISTL ETLKKEAAEV SRKASETETV MMEIEKTSQL YTPFSSYCAS
LYFTLDHLNQ MHFLYQYSLQ FFMDIFMHVL NKKSILDGIS DYSQRLNVIT KNIFKTVYKR
VSLGLLHHDR LGFALLLSRI YLKGMSERCD CSFDDEFSHL LMRSDSLKTA DTAPFSINGQ
LKLSKEQKEK LAQLVTLPAF ASLAERLAQT EGVLEWMESS NPEINCPILW DESKTTTPVS
QALYRLLLIQ AIRPDRLLSA AHMFIDVAFG ENFMSTGENI LNLKTIVETE ISCNMPLLLC
SVPGYDASGR VDDLSSELDR GLTSIAMGSA EGFDAAEKAV NSSAKTGRWV LLKNVHLATG
WLIHLEKKLH SLVPHPNFRL FLTMEIHPKL PVNLLRAGRI IVYEPPPGIK ANLLRTFGTI
PPGKMTKPPA ERPRLFFLLA WLHALVQERL QYVPLGWTKK YEFSEADLRA AWECVDTWVD
AAAHGRANLP AEKVPWNAIR TLLSQCIYGG HLDNEFDQIL LDCFIEKLFS EKSFQPDFAL
VNNVDSLGNK LTVPDGVRRE QYVNWVESVQ ALQSPAWLGL PSNAEKVLLT IRGQTMVKKL
LKMNDEDEEL AYTPIGEQFE GENHKPHWLK QIREAADHWL NSLPTSLAPL KRSVSNIKDP
LYRFFEREVN IASRLLNNVR HDLADLINIV EGNKKPTNHH RDLFAHLNKG LVPETWIKYT
IPSTTTITQW VHDFAERLAQ FQLIVDAVSS GRIKNLKNRL WIGGLLSPEA YLTATRQHVA
QLNEWSLEEL KLDVQVANTF DNLEMDDCSF GVTGLKIMGV SCSEQGRLKI SPKIWTDLQA
VQLRWVHGMG AEKQKLNNTV RLPVYLYTDR QRVLFSLDFQ MDPAILSVNE FYERGVAIVC
NGLMQMMLSK SRNLVALITG GASGLGKGCA EQLLKMGSKI VLMDLPTSSG AEVAESLHKT
DVVFSPGDVT SESDVSKTLE FCRQKFGKLD AVVNCAAIGV AFTIYNNTKK QPHPLEPFES
VFRVNVLGTF NVVRQSIGMM MEKELAEDEE RGVIIMTSST AAFDGQQGQT VYAACSGALN
SMTLPLARDC SRHRIRVVTI APGLFNTPLT SFLPEKVRQF FARLTPYPHR FGQPAEFGHL
VQSVIENPMI NGEVIRIDGG LRMPP
//
