ID A0A0V1HXA3_9BILA Unreviewed; 767 AA.
AC A0A0V1HXA3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Ras guanyl-releasing protein 3 {ECO:0000313|EMBL:KRZ15229.1};
GN Name=RASGRP3 {ECO:0000313|EMBL:KRZ15229.1};
GN ORFNames=T11_10513 {ECO:0000313|EMBL:KRZ15229.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ15229.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ15229.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ15229.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ15229.1}.
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DR EMBL; JYDP01000019; KRZ15229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HXA3; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00029; C1; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF252; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR HOMOLOG; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 106..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 263..495
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 529..554
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 558..593
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 599..649
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 657..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 87263 MW; 62A7794833039137 CRC64;
MENQYNSDVE YWQLNASAES QTSFRSFTLR YSCSIAGCAQ WVSIFHAFCP SDFTFSRKND
KKVLFKARGP GFGNALLSGA NKGAEQNCSQ LEEAGPCSVR RGRSTACIAS AVVLCVSVCV
CVCVLFPSSS ILEASLLADE ADIGRKMLET IVKFDLTDLR LQSRFTTIDQ LTQDALLRLD
ISLWPHTCRL IKLWMRLFPE HFRAPDLDEA IEQLKQQMIK IAPTRVKDHF PDLAKLTPYP
WSRYSSIKQP LTERISLSFD QWTPENLAVN LTHIEYKLLR RISFEEYKEY ATNSQLNAVP
ALQKSIASFN SISQWVQCMV LSKPLPRERA EVVTKFVNVA KHLKELKNFN TLMAVIGGLT
HSSLARLCRT MACVPHETRL ELSGFSNLLS SASNFSVYRK VLHMSHGFRI PIIGVHMKDL
ISLHTAIPDY SPEKMINCQK FSQLACIFTN LILDIQQPHL LSNANENLIN TLRVALNIPY
NDEEIYFLSL KREPKTLLQV RSSIQPAPVL ADWAEGVQNR VEPSVMQKHV NTMVDAVFKH
YDLNQDGYIS KKEFDLIRSN FPLIDAFNAL DVDHDGRISK QEMKLYFLRF RRNNRIDSRH
RFREVNILTP TFCYQCKKLV WNILRQELKC EECGIIVHRN CREYLLSSCF RRRNTEPASR
HRAFTEPPGS TNSAPSQNSV DDATVSRGNL FSLKRSKRRG AQATATSSTH ANLTVDTTAD
SKVRSFSEGG PNYINMDSMC ESIATLASEE VFETDEACEY DKNVKNS
//
