ID A0A0V1I457_9BILA Unreviewed; 3308 AA.
AC A0A0V1I457;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN Name=prkdc {ECO:0000313|EMBL:KRZ17567.1};
GN ORFNames=T11_17542 {ECO:0000313|EMBL:KRZ17567.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ17567.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ17567.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ17567.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ17567.1}.
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DR EMBL; JYDP01000006; KRZ17567.1; -; Genomic_DNA.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRZ17567.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2888..3218
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3276..3308
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ17567.1"
SQ SEQUENCE 3308 AA; 378593 MW; 419ECD5596EE7AEA CRC64;
LVSCLRFLLA LPTCIVVEKL ESIKEAIKSS LKLGLNYLPI ACVCLDALEK WSAEFPEDEP
QLDSFYTDLL PIFDDYLRCT SVDETLVVNN GFNYNGEKST FFNRKLRPVN TDSENVLDKG
DDNDSEEEMP NPQTVLRRIA SFVGSLGCYM NRFLIDSADV GSLLRWGQGS HLEFICPFPD
MKFEIALDTL LPRLCDLALS AGDRPLKVAA CEALHACVLF LLGNESFRTV KMKDRESISK
AYSHLFPVLL KLACDVDEVP KQMFSTLFVQ ILHLFSGTDF ADKMVTSCLL DTLMDGLCCF
WNSSLRDQSA YYISEYCRWS MRRVDSGGQN MRSESKVELL VQTIITFAVH SSAVKRAGAA
VAFNNLYKII REKRWLVDIY ILEMFFTFMK SLYLAENDDE LYGTVDECKQ AIKHIRRIIL
HNLDMLQIHN EQRRTPNEWS QSTVHCCCDW LLNTMTWSNC QFRSECFISY QELTNAGSEI
EKLHFLRHIG TSIFGFIDHF ERSHRSVLGS FSICNLQDRV VAGTSIYALV LWLETYEAMI
DGYVWALNTN RISMEAWNDY LLNEDPRVKS LLFPCSLDLV NSIVIGRHFP NLSKAQRNRL
NKTRCKSFVA LCKLIAALIS CQNLNNFQGF LKLLLYPNTW NAFLKVACDP KSLGFRLYSK
QLFECISQDV RLLFLALKNN TFLVQQVSTS MKEYLTQFYP WPDVESVVTC DSHLAIEQQQ
LLNVYGMLVE VGLQSVVELP RAEFLWTTVA DVYFSKRIGL PPSKLGMVKQ IFRVAALTGS
AVDVLIKLLM NTESVRLAEC SSLCSTKGEL LIANFSDEIA LLLCTNVELF LKHLKEASRC
QPDVVGRTLL QTVTVVVHSS DLRKNYGREL ALQILQIFGQ ELLYWADVAV SNETLKLLWL
KLIMKLILID SKITEWPEFA PMASAYFMML NDQSLTLDFK NRMLSLLAGF CTFDKHACEL
GRSLKLFMVN NFPLKSDEFA KGTAKYDQYV AACQKILFAF GCTGSPVILE LLLSMICREQ
SHPIASDLKH QLQKFSSRAN RTVLENILEL LDEMFFNPSS CVCASLRLSL LNEFFLPFLH
SLKNDLLLTW ACRKIQTLVS CLTESLTLEI KTDCEQQLIT KIGCYKICGI IYNELDLECL
KNEVNGSYLG SDSQMKNELI KKLVSCAVGA KKECCRDSKL GSIQRHFFEY RCAAQNCIIA
LVKKTQSHLK HYEGFIFNDC WESIIDNEVK YEFDREIQEE EQSAGKMYYS REEKPSSAES
ENQVELSVLL DSSLSVMATQ FDFTESLEVS IHCAETETES ANDKDVLKFY SKTKLDFLDQ
HPCMQAMVNV INYMDHMGMI PNDADTPLPA WMASMRDFLN FGSINVRLFI ARIIVQCFHV
FRPFYLEWIS PIIKLIVMDE FGSNILHYFR VDLIVVLFEW TAHLKEDEAI PKDSLNDLLK
FCVQHCWSKS GKVFKRNLRI IETMLVLWKP FVTLDPSLIL EKICFPLDDE NENVCGISIL
CLCLNTVPET FSFLTDPNYE SGIFSHLVGL LSLKKVKVYK LAAFVCGLSL KVLNELQTDC
EWLLKNMKAV MSRMTGTILG RTKCLFCLRE ILPNYPEFAL QFCNDLLDWF PSLQGDLKTA
CLEGFLAVSK YKGDLFEELK SRGFLKVFSL RYERDQVLGM YIVKNLHANL TVENISDLVS
SFSSVVGDFS SSCRRAFAEM CCSLYTKLSS LNDSSENSKA ALATTKMHLL TMLSDSNKSI
RQLVYNFWCD ASRLEISTSA RLLNCLSQLY TCATESTFLS HASYVMLELT CHSPDYTRLI
YDHPLEDCTF ENLPISTHWQ SRYASLEVPA YMQTDTHSVE QEVSKFISRK RKMPYGRTFS
TESTTAWPGF TPTAITDLKK NVGNISADTF ELDLDESDSS DNLTVILDKI LQDIKKPKSS
RVKKVDDLDG DLQFLKNRIL KDTEEKAFFV NLDRKRQKVI ERLKQQSLDL RGKYRRGDFP
DIQIPYSAVI ITLQAVAELD RVFAGQLFES LMCGVAANVI EIYNYEMTEK YFDSISDGVR
DIFRSMVTFH RPLVSCLMNF LYNFIEYVHF EPTDIANVAI GSGQPDCGIV LLERRIEVAF
VDISAVTCQE KRLRQVNETD RLWVELARLY KQCGELENLR AVFTKHLLTT EKTKLALEME
AAGDFEGAAA IYGETFSNKQ RKSGDIVEKA EANLLYEARI RCLEMLNDWK GLETWSTTFG
SIGQTTKLDQ IWETDYLINM HLPVFLRSKL KIALTSDSAA LEELSAFVEQ NQTVPKNREI
LENRHSGLLV LLNILREDFT KSQYFLNLAI DSFLKCYPTL RVCDVTARLK LVQDLLPVSE
TAKFLHLLHA SEHFKLENVV RLCRFWLRYG LDVETTLTTT ADDVVLNRKT FLEIFGKRLV
DSGISVSNVR QSLIPFRLQF GYQYLKCAVR QNNHGVVFSL LSSIKKLLQR LQDKHLLLEA
SNYETWALLQ LANCANAVKS RTDYLMQALN LFDLKRISDP EVNVTEGSSA DQFALIGMLF
DNVAETVVAS SENTLAEFCL SRLISKTDTA DISELVTLCY GQAFRYLKLS CQYSSQLNIE
SPKLTEPLME LSSFCDRILR KNGHTSLVNS ECACVMVRSI LKSMKNGSHL ARQLFPRLLS
VMEKYPESEL EFQAEIDSVP SWMFLSWMNQ MLSALKRSNK FYSILERIAD DYPQALIYPL
LMLKSATGDV GETDFYRLQL KLRKTKIVKD FIDALTLLSH PDIVFKHAID ELESIIFNIS
NKSNEARKEA IAKLFSFVTF TDIRRDFLGS FWKCYFKKYL PKMQEIFSVD LCALDNKAAE
NYLRLCSSFL SELRTFYIPE CCPNNLNEYS PWLTGYRPHP MDVFLEIPGQ YSGDRRPFPE
RHVHIIGFAS DIEIMRSLKK PKKICIQGDD GRDYQYLVKA GEDLRQDERV QQLFDLMNGI
LQKQHQCSRL KARIRTYRIV PLSIKLGLIE FLPNVVPLQQ FFMEESLRKQ YQTIAMEMFT
EGPGKILLKA AGEGSSPLNH LTYWRSFQNI TPETAAHCFN EVQKKIPDHL LRDQLLNCCV
SPDVFCFLRQ KFTVSLAIMC IANYLLEIGD RHLGNIVLDT KTGEVIGIDF GYAFGASLQY
LPIPELMPFR LTKQFVGVVE PVGMHGLLES TMKYCLKAFR DSSYILLNTM DTFVKEPSLN
WIVEARRQIG EGRTLWNDEA NLRDSFKWYP EEKISAAARK LRGDNPVIIM QDELMNSRQH
LSSFPLHQVI NCIYGKKDFS ALSEEDQSAP RGYPLQALTV EQQTSCLIEM ATDPVILSRT
WFGWEAWI
//
