ID A0A0V1KVS4_9BILA Unreviewed; 791 AA.
AC A0A0V1KVS4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Glutamate receptor ionotropic, kainate 3 {ECO:0000313|EMBL:KRZ51419.1};
GN Name=GRIK3 {ECO:0000313|EMBL:KRZ51419.1};
GN ORFNames=T02_10 {ECO:0000313|EMBL:KRZ51419.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ51419.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ51419.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ51419.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ51419.1}.
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DR EMBL; JYDW01000227; KRZ51419.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1KVS4; -.
DR STRING; 6335.A0A0V1KVS4; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF588; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE GLR-3; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRZ51419.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..791
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006881267"
FT TRANSMEM 492..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 362..730
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 372..436
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 791 AA; 89488 MW; 8A713138776EE038 CRC64;
MRSCCCWLAI LFLLISNLVA KVFWLSSLFG KRDVAGRIAF YVAVDQYSTS SVTFKSRMLS
MENDEDVVEL VDKGNENVRL LCESHEIPLV MVKFDDSSKP FFNSIDLYPP STAVGTVISN
LIKQFQWQRA VILYQDNFGR QFRPQLKQLK ELQHIYFFVV QADLVTVRKF LDDAMEMNML
GPYYHYVFTD LDVYTLDLIP YKMKGCNITA IRFVDDDAPV TKRIIARLKN HKATNGSWPI
FTSGTLPTYV AVINDAVSVI TKTAIVLQNS LKPESIDCRN ESVWRGGTTF MNFLKATAFQ
GSTGHIQFDG YGKRFNFSMQ IVEATTQGFV KVAAWTQQRG LEHVKSDLPK TAQIAESLEN
KVLRVTVYME APFVMYKKSV EKLSGNDRYE GFCIDLLERI AEMNKFNFTI HEVKDKSYGT
PDANGRWNGI IGELINGDAD VAVASLTINF VRSEVIDFSV PYMHLGISIL FKKPEKTPPS
LLSFLAPLSL DVWMYMGAAY VVVSLILWLV ARISPSEWVC SHTCQGEEEN KENQFSLGNS
FWFTIGSLMQ QGCDIAPRAV GTRMVASVWW FFTLILISSY TANLAAFLTV ERMEYTINSA
EDLVKQTKIR YGTLNRGSTM QFFKDSKIPV YEKMWMAMKS SEPSVFVNGS REGISRVKQG
NYAYLMESSM LEFYVERDCD LTQIGGLLDS KGYGIGFRKG SPYREAISQT ILYLQEKTVI
TELKDKWWKR RGGGKCDSAD GKSSISAELG LQNVGGVFVV MLLGLGLAVG VTIFEKLKTY
TRSRQQKNDN N
//
