ID A0A0V1LB55_9BILA Unreviewed; 2979 AA.
AC A0A0V1LB55;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KRZ56709.1};
DE Flags: Fragment;
GN Name=Nf1 {ECO:0000313|EMBL:KRZ56709.1};
GN ORFNames=T02_12577 {ECO:0000313|EMBL:KRZ56709.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ56709.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ56709.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ56709.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ56709.1}.
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DR EMBL; JYDW01000089; KRZ56709.1; -; Genomic_DNA.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:InterPro.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:InterPro.
DR GO; GO:0071025; P:RNA surveillance; IEA:InterPro.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR004405; Transl-rel_pelota.
DR PANTHER; PTHR10853; PELOTA; 1.
DR PANTHER; PTHR10853:SF0; PROTEIN PELOTA HOMOLOG; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT DOMAIN 1345..1560
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 534..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2590..2609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2695..2781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2707..2727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2762..2781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2979
FT /evidence="ECO:0000313|EMBL:KRZ56709.1"
SQ SEQUENCE 2979 AA; 334152 MW; 5B58EF1BE3F7A63A CRC64;
LLSNGIYIYF CRKLKLFLNV MKAFSFQKPL EWVSSLLARF EDQLPVKTGP LKNQSRLLLE
QSRACLVNVS KLKFSMVVGG LIRVLQTVNS MKTSSEQDLF DSQCFILDTL ERCLAGPQDV
SSRIDEANNV KIIIHEMCQF IQLSSDSNQA IQLKEKASKV IYNLSLSSFN VIFNRIVAKL
KAVSCEPSAV SVPSDLMASS SDNVDIELMQ YIHFDLKSLI KLLREISYHK PFKKENNQIL
FRSLENVIWN WMDTYPDEFH NLQVEQNNEL NDCCDRLFDQ LDMYGAESSK RKAIVWPLQM
MLLILCPKVL EEIHHISCGA PCPIRLVKKK VFFDSIKKTM SQGHSHTCKH HLLSSACIAG
VKLCKAAIYV NVVDSANVFF ALLQSIITDL KSYLFNPIKP LFKNPSSAQE LDVMIDCFVA
LFRLSYNNEV FRICLNAHTV VPHQLVLVMA LYRIAVQARL PWWPKIDLVY SRSGELLQMF
NETLSRVCQG VSVVGCLLPT PSSTTCQPSS HGQTSTTHMP LRVTHSLHRM TGKLKEKSLA
GSQPSATGGA GGGAGGGGCV GGCTVASAAS VSSLTGNANS SSVEDGCQQL LFWLIRLMCI
EPTLFLHHGP ESTSTVAPSS STAELISGLV NLVGNSNQMP ELAQEAMEAI LCLHHPENIR
MWHPDSTFTT VQSLWYISSQ LLFYICQKLL QFQLANFSET LRWLRQLLVY RNLYLLSNRE
IANYGSSEQL CKQAAQKLET VCFVYLWSLD NDTAITALSV FRILCEEAEI RCSGDELPVE
YADHAELASA TNLQTVGRVV LQKSINSYLK KLLIPSAGCC EAWEATYRYW EALTKFLKAY
PKSKQEDSYQ VVENLIKQLV NQKLGRSSEQ EFEMTVKLWA NMTGFLCSVG GVVIKSCKNT
TLYYDSSGNL PPSAETSDKS TTATADDLST STPDLFCSVN NFLSQLLTLL LVQSDKLEVA
VVRHIKEICS YELHQLLIGH FFEQIRTITD RFIDNDDVII ICLKNTEFIE HVVYIMKNIL
LGCCKQNVRN VEISCIEPIM LNLCRYVHNL EVNYQSVTIK GKICQLIEVI MRNYENIIFR
SEIRFRNRLV DMIADWVICN NSPSASSCIA AVVGVGAFPS EASLPLRDFN TLCMVALGAL
MRDLPLQPNC PPNLTTGQTN VQNTAMLNKS QLFQKHFGLF MNVLNDCAMN ENTGAGDFDV
ETVSRGDETS SQPLVNTSTS SSVPLVRGAG RAGAGAAGVG RRFRETKTEQ LRRATILAMS
NLLAANIDIG LVHAVGMAYH RDRRARVAFV EVLTKILQEG TEFETLNETV MADRFDELVK
LTTMITVDGE LPIVNALASV VQTEHMDELA RVLTTLFSSK NLLHELLWKL FIKEVELAEA
PTTLFRGNTV ASKVMGYCFK LYGAKYLHSL LHDFVNSTVE HSTSNYEIDP SRLETDDNLA
ENTTNLMELV ENILSLIVHS ADRFPVQLKG MLNVLFYVVN ARFPNTGLLA VGMIVFLRFF
NPAIGSIELS NVKYITLFYY ISFHFMLVSP FEYGLTENYP NANVKRGLML VSKILQQIAN
QTISLKESCL QPFNAFIQSK FEPTRRFFMN IAVEFRFDAD ASSQYYMSYM NDTPTCALHR
LLWQYQDRIG EFFTTMRSHD RVARRLATLL AQLGPANGRA GSKQWTNVDL NSTRFEELMS
RQSAADKDEY NSIKENNIFY QCGISRASNP VFYFIANRFK VGEVNGNMLI YHVLMSLKSK
RNEHFELVVD LTHASTENRF RTELLHKWFL VLSEAMQQNI IAAYICNCNS WTRDYIRFHE
RLFSPLKASH KLYFLDHVRQ LNDYISPEWQ RLPASTLQID DDVLTFNNAL KICHKNMKCS
IKVGPTSLQI TTLDRQKVLG HNVILNDVYY ASEIQEVCLV DDNSMTLTIL NECSPLTLMH
ADCEQIASAV VNLRTRYELS QPDQAVLHAK IRAKDVPGTL LNMALLNLGS TDASLRTAAY
NLLCALAATF NFHIEGQLLE TEGLLIPANN TIFIKNISEK LAMNETHLTL EFLHECIQGF
RQSPIDLKHL CLEYITPWLA NLPRFCRVSG NDNSKRRAVA KVLDKLITLT IEEIEMYPSI
QAKIWGSIGR LSELLDIILD RFLKRSITGG FGSMPAEVMA DTSVALAAAN TKLVSDILIG
RLMQVLEKSC LNPQATLEEH ILWDDIAILA RYLLFQSFNN CLDVISHLPV LFHFVTVLVN
TGPLALRASI HGLVVNVIHS LCTCPSSFSE TTKANLRLAL TEFFLPKFYR LFGVSNLTVK
SVAATAFRIS PRMSLPIHCS GDYMASGSIA PRQDRLTLPN LETIADSLVD LLETCNQDIK
NRNLCNEWEK ISYYFTMRFN PALQSRALVV YSCLSKKTDE SVIKQLLNLL LQFVKRRDDC
SLLSAVLMAL RRLTPLLPSV VLQAIHCTLL ARLFWISVII LQLEDPSLYE HGLALLEQIL
RSLDSLNVFE YEPFEKVMME ARPLLEWEFK AMDQQMGISF KHNFHFAVVA YLLKGYRHPS
QSVVSRTVRL FSLILGIVAK YTKRDRYEVT VENVAYLVAL LPVSEEVRLR CPLRHSTLRA
LSLCGPSENA SNNDPTVGSF PSPGRADKLQ PCSRRSALCI QRLQRSCDDS LQTLAVAGST
VGSGKLMRTV TGAGDTLSSR MWSPSSSSSS SVSSMAVVGF TGQRSRSLPL SELSTCSLSL
PHGDNREQQK QQQHEHEHPD KTEQTCKNSN GDDGPGDLAS KTTAAEITKS EPTDESQESK
AEQQRLSNSN GKSGGGQTGQ SSRTAFYENL LLDEDVLCEP SLQVLVLTVL GTLVRNYADE
NETRTLFEYL AEASLVFPKV FPVIHCLLDQ RITQVLQMSH DAAVLRAVLH IIQNMIPSQE
TTDTYQQQHL TLLQSYGFGG FWRFAGPFSL KSTAQLQIAP ESLTCLERLI GSLGEVHLLT
PPPLSPFGTS EFGYFRQESF SGTSRANSVT LERSATSDC
//
