ID A0A0V1LEH2_9BILA Unreviewed; 716 AA.
AC A0A0V1LEH2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=Dhx33 {ECO:0000313|EMBL:KRZ57818.1};
GN ORFNames=D917_06695 {ECO:0000313|EMBL:OUC47758.1}, T02_12371
GN {ECO:0000313|EMBL:KRZ57818.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ57818.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:OUC47758.1, ECO:0000313|Proteomes:UP000243006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS45 {ECO:0000313|EMBL:OUC47758.1,
RC ECO:0000313|Proteomes:UP000243006};
RA Mitreva M.;
RT "Draft genome of the roundworm Trichinella nativa.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KRZ57818.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ57818.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ57818.1}.
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DR EMBL; JYDW01000068; KRZ57818.1; -; Genomic_DNA.
DR EMBL; LVZM01003872; OUC47758.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LEH2; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR Proteomes; UP000243006; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd17978; DEXHc_DHX33; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KRZ57818.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT DOMAIN 43..211
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 237..441
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..337
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 81481 MW; CCBEE8B28B2AE357 CRC64;
MSKKHRKKKK SESKKKKHSR PHVEKLKQAR QKLPIYACKE KILRLLKDNQ SLIIIGETGC
GKSTQIPQII YDEWLHDGMV IGITQPRRVA AVTLAKRVSE EMNVHLGQEV GYSVRFDEVA
SSQTQIFYLT DGMLIREAMF DPMLERYSFV ILDEAHERTL HTDVLFGVVK QAQRKRKARK
LHSLSVVIMS ATMDADRVSK YFNNAPVAYC QGRQHSIQTF YCSGSFTDDY VLNCLISVFQ
LHRTKPPGDG DVLVFLTGQE EIERAVRKCK EASEHLSSGT YGPLIVLPFY AGLSTHAQMR
VFKEKNDDEY DREKKKLKSK KSSKHSSSSK KRKDEKKQRR VVIATNIAET SVTIPNIRYV
VDSGKVKLRC YDPSRGIDML KVVDISKAQA DQRAGRAGRV AAGECYRVYD EQKFDKLLDH
TEPEIRRCSL TGTLLQLLMM GIRNPNTFDF IDPPTKESLE AARLVLSQLG AVVVHREKLS
LTDLGRTMAE FPVEPKLARL ILASAKLHCS EEMIQIVSVL SAGSVFVEET VENDEDAQTC
RRSQKFFQPE GDLIRLLQVF RAWQAVRGIS ISQSDARREW CKEQGMHYRA LYSAGKICSQ
LRRICHSLGV PLTSCGENWK ILRRALCYGF FMQAAFLDEQ FTVGKATTYR VLGSDLRAKI
HPSSCLYQHK PACLLYAELV LTNDLYLRDV TVVEPQFLLD AAPDYFAAHH IELFHS
//
