ID A0A0V1LGJ8_9BILA Unreviewed; 1762 AA.
AC A0A0V1LGJ8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Protein HIRA {ECO:0000313|EMBL:KRZ58640.1};
GN Name=hira {ECO:0000313|EMBL:KRZ58640.1};
GN ORFNames=T02_10259 {ECO:0000313|EMBL:KRZ58640.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ58640.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ58640.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ58640.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ58640.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDW01000054; KRZ58640.1; -; Genomic_DNA.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.10.520; Ubiquitin activating enzymes (Uba3). Chain: B, domain 2; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.10.290.20; Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR023318; Ub_act_enz_dom_a_sf.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 13..394
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REPEAT 589..620
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 645..677
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 688..720
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1246..1441
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
SQ SEQUENCE 1762 AA; 196572 MW; BC8DD87EC53DE58B CRC64;
MGENQEFLDM YHSFTNKKLL VVGAGGIGCE LLKTLVLSGF ADIEVIDMDT IEVTNLNRQF
LFRKEHVGLS KAKVAVESVS VLNPNVKLVY YCEPIQSREF NVNYFKKFTA VLNCLDNIEA
RSYVNRMCLI CHLPLIDGGS LGRKGQVDVI IRNITECFDC HKHSPSHDYP SCTIRNTPTE
PAHCVIWAQH LFNQLFGEVN SDQDVSPESL VTGEEFEATP QVQPLTNIIS LQDLAKNHNY
DPEVIIKKLF VNDIEYLRTM EKLWEGRQPP TPLNLRWFRI GLDESLQGTE QKDWESRDQN
VWTLKECFKV AVSCLAVLKE RAKTAPLIWQ KDDPVCVDFV TAFTNFRCHV FNIEKIPRFE
AETIAGRVVP AIVSTNAVVA GLMVLKLYAV LERRKDFYGS VAISSQEGMP RVLSIAPSTE
VTGCEYCVAV KEVEVSLNVS TFTVENLGKI AKELSVMKPE IMLEVASPRL LFAHDYKLSA
EEGKKTLSEI SVKHGSLLRC EDGATFTNIR IIISDCGVFD SIELIGNEVH KAELGLPIYS
VDIEPAGNRF ATGGQSVTGI GLIVLWSLKP VIDVENETND KIPLLLCRLE AHSTCINCIR
WSSNSRYLAS AGTDQAVKIW RFVSYIPNVQ SRVTAVEHWK CISTLHGHAG DVLHLSWSPG
DRYLASCGID NIIIIWNAKK FPEKITSLVG HEGFVKGVCW DPIGKYLASQ SDDKSLRIWS
TVDWNVVHKF RRPFKEAPCA THTLRLDWSP DGLLLATAHA VNNGGPVSKI IERNGWKCEL
DFAGHRMAIT CVRWSNVLYH RNRKVFLTEK SNVCSCCAIG SKDRSLSVWS ASENRPIVVL
TDIFESSISD ISWDSSGLIL IAASVDGSVV CLVWTTDELG VPLSLDEKIN KLRRYYGNVD
VGLLGLQRKS DQNSHKIIED ADYVMTHAKV IANRSNENGV NGGVCASTTA VRTAPPPSTP
DTNWNVQLET RTKSGKRRIT PINVEVVAEV DTDNNSQPPW IREGVGLDVA GNAKGLNDEI
MTVIDNAERW SGLNSTTVEP LVPLVASFSS ASASKSTLVK SRKGDNFDAG GKSILKSSKD
HSGGIVEEFL KKSKSELKFD KKKSWHQKGK KALKHAQRES TISQTFPSSG TEVEVETDFQ
THQTVAVSSS SKQQTPTHRL EALKVVQLLM SSVVVDESES EVLLQLSNNM GSKPKGKFAE
LLCMKNSNCV WKILLETGAV ALKANRHLIL VVFENGMFDI LSPLDGRMMC LTNVLGDSVH
YVNLDGKLIA LVTVCAELYV WSFVKSLELV CQVSLKALLR DPKRNLSRIV FSADGMPIIS
FNDGSLFIYD ASSKIWQKLL NPSDSFIKYS PTSMLASTKA YLKTKGRFQN LCKNLFSSVT
FTAESDSEMQ ERIREGFLER FSLASRAVGS EHEYMYWLSE YVKLLVKAES EVKLRCLFRT
LVESDEHMKT NSMLSRDKSE KRSAVTDLLP LVAANPKLQR LYSELSFLVA EKSSNEQADD
LYSEIAATKK QKDLFEIAEE CGATNSLKLS CDVMSVEKFM KSAPEEKSSH MSMAVILLNK
MNKRCVGYIL KSDKDSSSGS RFILTTRTCS AKQINAPIYI LPENKERHVK AIHTRGFHES
LAVIEMQDKY AFKLASESTC PLEFPEISEE CFTVYAVESQ VNKRDIVAEP YKSSPKSSCE
KYWITFSEES FACAATGQKE KRNGLGLVCS QGGKLALVGI SSENQQTTSV TSFTLLYPYA
KHFWKMSCNV LQQKMKLHGL HF
//
