ID A0A0V1LLJ5_9BILA Unreviewed; 1637 AA.
AC A0A0V1LLJ5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:KRZ60231.1};
GN Name=Apaf1 {ECO:0000313|EMBL:KRZ60231.1};
GN ORFNames=T02_6095 {ECO:0000313|EMBL:KRZ60231.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ60231.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ60231.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ60231.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ60231.1}.
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DR EMBL; JYDW01000031; KRZ60231.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LLJ5; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:KRZ60231.1};
KW Protease {ECO:0000313|EMBL:KRZ60231.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 141..212
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 55..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1584..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1584..1611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1637 AA; 185326 MW; B4A6947BB5DB6533 CRC64;
MPSEGKASDA HTSGDYISAM CIICCRSRRE LCQRPDTNKA CSNCDCCQSK QSEGEAEGEE
TTSEAEEGEK PEEGEEEMRP GVEQQVPLDF LSQGVDPAAR LLHRLHYGKQ SQLLQPRFCP
CPTAKDYNEL CLYWAYTGLC NRAPYMNTIE EQNLKLLNSQ HSLLTDLEPK EITAYLQAAG
VFSEDDIELI NAKVTRRERV AELLTIYRRK ARDLGPLVYA LDKTGYRHLK IELVNSVSQV
DRGAVPNSKH SLNILLINGK VPRKPEVYVE RKEMKLKLKT ALMRIDKEPG WIVLHGMGGC
GKSVLAAAVV RDSEITGGLF SRVFWITAGR NCDRIRSFAL MQDLYSKMGK EFHRLDSVEE
ASSRLIELML FDYPRTLLIL DDVWTESVVR LFDELQCRIL ALTRNASLFD VANNRKYFVL
MEPSGYTRDE AMQAFASYLN CSESDLPLEA LQIFHECRGH PLLISLIGAL LKEHNSRWKF
YYGLIHSQKL NNIKKVTHYK YATFNEAALL SLEDLTDDLK QLYFELAIFP LGVKISSQVL
TVYWNKSIYE VEDIMAEFVK RSLLIKSSSD CEAVETYQIH ALLHRVIKMS CHSDLRKTLH
QKLLGNYLKV ADDCWGKLPD HEYIFTFLGY HLFRADKFAS FSDVFLNLKF LAKKIALCGP
SSVLNDLIYY RKFIRDSHPT LFDQIERLIK NNSFQLATNN GKYLSLIHLS LLNKNLSELY
LEAERILQES DSSAVVDGFA KPYLKSWCKQ SFGKDPNFTF SCNSVKTGVW MSRQKKIIYI
GFDSCLGVCC TTTGLQLYRV VLNHVPNYLS FSDNDCTLFV AYGNYVGVFE LDDHLKRSST
ETEDDLDCQR TPSPILNHLC NGLGFIRANE QQQDQKHQDQ QQQQQQQKVD ENILGPKLLQ
VREFEVDDCG VELRFCLPAR HYPWVLCCDM EGSAKILEIS QGRVSGGLDL QSRRNDRSTT
MHITSCGFNG DDSLLAIGRA DGVVELWNPA DFGLRCRFAG HHSGPVQFCA FTGRFTSVEC
IFSACERRIL LWKFDHSRDH DNDLQQSNSV ELLEKIQPDQ KHVRIVCVAL SPTENLLAAS
FTDFSVLIWN LENKLSTYLV GQCRILKQLY FSEKGKDLLA VREDNAIFNE IHKSNTSIPE
INLIDFVEIK TALLLASVQD YTLQVSIITD TVGSVIETRR LFDSVSCLKW SPNECVLMIG
FENGWIQSCQ FDGNSLSELK KEFRTPQAPC CLAFSTVSDR FAVGCKEGCV AIQDAVIHCQ
GTAFFETAVT KCIFIDRHPH MNRLLICLQD GSFEILNIDS FVVEAVLGLP VCMIIDFDVN
SNCTYLATCW SGKQVKVWEL DNLNPIFEEN NFNNSLSKCK LSQSGNLLAV CESRGMVNLF
KLPGGDLVQK IYAHSADIYD LVFYDDDDVL ITLSAELKWW NLKLKSNQMR HWLLSTDSAK
TLNIFPGHNL LVTVDHMQGY HVMQIVSTGN LPVGRISAST SIPPLSSVVE KFANASPPTI
QNEQQLFDSL PAELQAILVT DDFGMQSISK LPNELINEDS FATFSTIFSE IPDDQSPTDQ
NDEPVPLDSA ETLLRHVFDL YSHDEAEQPS AEEMDTTETE DPKKIPSEVK GKKSVAGRLA
SIFNIATQLY TNSHYFA
//
