ID A0A0V1LP21_9BILA Unreviewed; 2376 AA.
AC A0A0V1LP21;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Fucosyltransferase {ECO:0000256|RuleBase:RU003832};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU003832};
GN Name=SMC1A {ECO:0000313|EMBL:KRZ61237.1};
GN ORFNames=T02_2848 {ECO:0000313|EMBL:KRZ61237.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ61237.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ61237.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ61237.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Golgi apparatus, Golgi stack membrane
CC {ECO:0000256|ARBA:ARBA00004447, ECO:0000256|RuleBase:RU003832}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004447,
CC ECO:0000256|RuleBase:RU003832}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 10 family.
CC {ECO:0000256|ARBA:ARBA00008919, ECO:0000256|RuleBase:RU003832}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ61237.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDW01000020; KRZ61237.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LP21; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0008417; F:fucosyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0036065; P:fucosylation; IEA:UniProt.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.40.50.11660; Glycosyl transferase family 10, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR031481; Glyco_tran_10_N.
DR InterPro; IPR001503; Glyco_trans_10.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR038577; GT10-like_C_sf.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF12; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF17039; Glyco_tran_10_N; 1.
DR Pfam; PF00852; Glyco_transf_10; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00458; RICIN; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003832};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU003832}; Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003832};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003832};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003832};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003832}.
FT TRANSMEM 2015..2036
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003832"
FT DOMAIN 1880..1945
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT COILED 198..256
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 300..327
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 356..397
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 449..525
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 838..958
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2376 AA; 274530 MW; AA694CEDFE481441 CRC64;
MVAICVRIDF STLNDLISYF GIAIKILHYF VLNLGHFLMH AEIKASNLKT LNPTKDTKEL
GHSKNSLQSS AQMDQSNLMD AICFVLGEKT SSLRVRKISD LIYGAPVGKP ISTRCYVAMT
YEDDDGRILK FMRLVAGASA EYRIDGATVS HLQYTEALES INIFIRAKNF LVFQGAVENI
AMKNPKECTL LFEEISRSGE LKAEYETLKA EMMRAEQDTQ LNYHRKRDIA AKRRAAKMEK
EEAEKYQKLK DSVAEKQSRY YLMKLFSNDR ESKRIFGEMN GKHGEQSRIA TKCSEVEEVL
KERRKVYSKV TREVNKLEQQ IYEMESEITR EKPSFIKVKE NVRHSERKLE AFHKAFEAAR
KNAERQQEVI RQFEVQLKEA NEQRDAFEAQ LMQESESQGL QLDSEQLAQY NSLKGEVVRQ
CASIQQELDV LAREQQMDQE LLDNDKRCNS EFCQKIKQKE SELEALKKRL EKLVDTIRNT
ENEIEEQRSS LRSTEDEVRT AKTRLEQVIV EVEDVNRQLN DANVDSSENS RIVKKQELVE
NLKRISTGTV YGRVVDLCQP AHKRYQLAVT KILGKYMNAI VVDTEKTAKE CIQYMKEQRI
ESETFLPVDY IDVKPLNEKL RELREPRNVK LIFDVIQFEP PQIRRVVQFA CGNSLVCESV
EDARNLAFSG AERHRAVALD GTVFEKSGII SGGAGDLKAK AKRWDEKAVA HLRSRKSALI
EEQKELHRIR RKEPDISLMQ NSVKQLETRM KYMLTDKENT ETRLLKNLES DLMQLKAETE
KYGPRIQEIE NRMASRRSNI LQNQSRMNQV ADHVFADFCK SIGVLNIRQY EEREIRFQQD
KKQKMMEFDN QIEKLKNELE YQKSDDKSGT VISAGIAELA HLEKIEASCN KEERELIKAK
KEEQEHIRLL ADLESQLKDL KAMRQTKKVE LENKEAELNE VKKELATIQK ELLSVQKQTS
AMETLLEQKR SERHSLLQTC KLENITLPII RGSLDILSTT VSSQSSDTTS SVVSEDGATT
LSSTSFMGNR QLYQLEAEIT FDFSSLNPDD WELSDDTELR LAAEKLLKEI GETQAFLQTI
TAPNLKASAK LEGVRERFAE TSGEFEQARK KAKNAKMAFE IIQKERCSRF NRCFDQVSGK
IDEIYKALSR NFSSQAYLTA DNPEEPYLDG VSFSVVAPGK RFRPMDSLSG GEKTLAALTL
LFAIHSYNRA PFFVLDEIDA ALDNTNIGKV AAFIREQAAN NMQLIVISLK EEFYNQADAL
IGIYSVVCVC MFWHILFLEF NGIPILRNAP VSYSKDWHNY TQMMLDRARR GKKISFYPGV
GEHGNPVELP SSVAEKAEFD RLYKANGYSG WTSDKISLYR AIKDLRHADC KRKSYLLLLP
STSVIVPFHN EHLSVLLRTV YTIVYRTPPE LLLEVILVND ASTKPELNDI LERHVQRKFP
NLVHVIRAGS DGRREGAAKA SGQVLMFMDA HSEVGYNWLP PLLEPIKLHY RTVTCPFIDV
IDCDTFAFRA QDEGARGSFD WKFHYKRLPL LNKTGAEPFE SPVMAGGYFA ISKRWFDELG
RYDDQLMIWG AEQYELSFKL WQCHGRMIDI PCSRIAHIYR CKFGFAALFS TVHRYAPFED
PGIGNFLERN YKRVAETWMD EYKEYLYLRM PRLRNVDPGD LTKQREVRQR LKCNGFDWFM
KNVMFDQPKH YPLVEPPDVM SGRIKNKHTG RCMDVKNAGL QTELTTSQCK DYLKRQEFVL
SWRSEIFQRL GENCLDSMNH GPGETVHLFA CHGGGGNQNW TYSRNTTMHL QMTASNLCLD
TDNTGRLFLN TCQLFCFCGG SGKTRCMQWR GFIYLFNLLT ASFCSADYFK VNNNKNIVQS
WMNSIVDNKM DLFQYAANDD YYNILGCDAS STMEQIVAEF RVRAKKLHPD KNSKSTSANE
DFARLSRAKE ILTDPHLRKS YDLWRNAGLN IPFDDWLRKA NALRSSVHWF HESPTLSIES
SSQYANKFSS ASNARDWRSE QSSLRTKAKM RTISSVHLLF SGMLFILCVF ATIHYLSYFR
LAKIIESIRM SEDVKILMWT PFFTETISQT YLSTCPELKC SIVNDRKDFH NSRAVVFHDR
NIILKDLPTV RKYNQHFVFF LMESPYHTSV AAYPHLSTDF YTKTMTYRRD SDIQIPFGYV
QKRKSPRPFD SDNWYQLAKG KTKMVAWWVS NCRTPSKREE YVAKLGQYIQ VDIYGNCGNL
TCPRSMTKEC AEDLRRDYRF YFSFENSICL DYVTEKFFDR LNDAVVPIVP SRKIYENLAP
PNSFIAADDF PNPQALADYL HFLSKNLDDY LKYFDWKKEY ESISFPYGMY RAFCTLCQSL
LNENPHYLVQ PTPSAANVSA WYSKPGIDFF QHFTSI
//
