ID A0A0V1LUG2_9BILA Unreviewed; 953 AA.
AC A0A0V1LUG2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN Name=Telo2 {ECO:0000313|EMBL:KRZ63141.1};
GN ORFNames=T02_11869 {ECO:0000313|EMBL:KRZ63141.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ63141.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ63141.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ63141.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ63141.1}.
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DR EMBL; JYDW01000003; KRZ63141.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1LUG2; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.8.1120; Histone RNA hairpin-binding protein RNA-binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029344; SLBP_RNA_bind.
DR InterPro; IPR038294; SLBP_RNA_bind_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF275; LD03170P; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF15247; SLBP_RNA_bind; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..279
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 357..452
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 477..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 953
FT /evidence="ECO:0000313|EMBL:KRZ63141.1"
SQ SEQUENCE 953 AA; 109284 MW; 3F84EEAD6A48CF40 CRC64;
LVRWQRLDEK CPDRETIDRI DLVEFNLISR TIRAKKYLQS IFRDCFRSVF SISHSNCRIG
KNAHVRPLSS KRFVGFDSSL CKTRPMLKLR FKQPKHAWIL VMEKMSEKCD GGLPEPSTET
QLAKIYDEFV TSERHYLEHL DLVIRYFADP LLCSKILTQR EVANIFGDLR SIRLVNQVLY
DRLMAGLEIA EAFGDLIHFM KLYSAYGRNY SASQQLLLQL LEKNKHFRQF CEMQECLPVL
KGLKLAALLI TPIQRIPRYK LLLEQILKLL DNSSRQHLQI SSGFSLIFAL LYCYISIALV
IYLLSGEILF AELVQQIGAL AETVDSCIEE FENSAKIIAV QNMLDGCAPK LVMPGRKLLK
EGLLNKMSSS NSGFRHRMFW LFTDIILYAK PAMKKKNRYQ CCCILPLRHC MIERILGRSM
FRLICKDEVL LLHAEQYSVM DEWVVAIENA IRYLLECRKS LRKESSNSFP MHRQALKLHR
SRSSFTEKLS SRKTQIPNDD PKPTKKRRSF LLSLLSKLGG RWSSRNRRQS GDDSLAEVET
NNSRMTNSVS LFSTGSRLPL DNIAEETSIL GRRPKEPPPK NHRLTLVLCK KSRMKMSPIP
LNWLLKSNRY DYSRRLESSS LSTSGIKSSV FELFGECDDY VLGMGYCLVC LFVVDTQQNE
ANVIAPFVEE STSETIVPEH EVAAVDFSQL HSTYAQQMVS KSEPSHEEPS TFARRNRRMR
RPVAPGPRAS KQAEADANEE LKQGSQWTRA RQPHLLNEEN TLEAGDVESD KRKEETLPEV
VKPVEEAPKK RVGPPLRYPL PATWREPTNG WEEDQAVLKR RQKDLDKGYN TEAYKKYIAA
VPNRRSWDSQ VRLWRKMLHV AVGEEYNSDA SFVSSSSCSD ASSVVSENEV TSLRRLSENE
ESVEVGRKVD PVNESMPINQ QDDETLTEEN AATLEGAIDF SDLMKKSSSL ENP
//
