ID A0A0V1M7U9_9BILA Unreviewed; 505 AA.
AC A0A0V1M7U9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Triple functional domain protein {ECO:0000313|EMBL:KRZ67864.1};
GN Name=trio {ECO:0000313|EMBL:KRZ67864.1};
GN ORFNames=T10_8813 {ECO:0000313|EMBL:KRZ67864.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ67864.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ67864.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ67864.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ67864.1}.
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DR EMBL; JYDO01000183; KRZ67864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1M7U9; -.
DR STRING; 268474.A0A0V1M7U9; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR PANTHER; PTHR22826:SF106; TRIO, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 5..180
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 198..306
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 341..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 55764 MW; E0C252D7E1463761 CRC64;
MCWVEETYVL QELVETERDY VKDLGSIVEG YITTIESMEL PEDMKGKERI VFANIQQIYE
FHKNIFSKEI EKCLEDYEAA GRAFVKYERR LHMYVVYCQN KPKSEFLVSE YESFFNDIKQ
KLGHRLTLTD LLIKPVQRIM KYQLLLKDIV KYTARANEDT TVLNKALQVM LVVPKACDNM
MHVGRLQGFD GKITSQGKLL HQGTLLVSDN PSPQLFKPKE RRVFLFEQSL IIADCIPSKK
EFGCPNYIYK THIMINKLGL ESEVPGEPLR FILKNKDPAN QVDTVVQANN PGEKEQWVSC
IKQLLDTQMN FLKALQHPIA YQKGLSKDDS KEEVTVELTT NTGIGGAGGS GRLNVSSSGD
FAEESPARGM LNACSRSRSQ NSNLVVPNSA SNVSALRRAS NAEGSVVETT KKSHVLPTRP
GHLIAGAKDG TSDAASPRSS KNKLFGGIRH TLKSKTGGTT GSTAAFATAA TVAANTVPST
TNSRSCGGSK TIKSPTSPVS GIKPK
//
