ID A0A0V1MC76_9BILA Unreviewed; 1699 AA.
AC A0A0V1MC76;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Voltage-dependent calcium channel unc-36 {ECO:0000313|EMBL:KRZ69353.1};
GN Name=unc-36 {ECO:0000313|EMBL:KRZ69353.1};
GN ORFNames=T10_11876 {ECO:0000313|EMBL:KRZ69353.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ69353.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ69353.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ69353.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ69353.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDO01000138; KRZ69353.1; -; Genomic_DNA.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF37; VOLTAGE-DEPENDENT CALCIUM CHANNEL UNC-36; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 286..471
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1304..1356
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
SQ SEQUENCE 1699 AA; 196375 MW; 3091F565408326DC CRC64;
MRNAEFFNEV AFACSVHHQI VIFIFQFNEK QVKNPMTETS SAGLRFTLIA HLLMKPILQA
CFSSCLFWQQ NYMPKICVVE ALFQSALQLL NNGRKKYQEK NARVEYFDPE EVIDVMKARL
EKFLGRRRQL AEILKENLEN SYSLFQMVDR EAINDLQSDD FYRFVDSKSC LNRHYVDPLL
INSSLSVNYI PNPNFFNLPV NTEKSAVHVP TPVYARDPEL LSEIIWTESL DDIFKARRAR
EFFAASWQYF CSQKGFMRFY PASPWFYDDS HTCLDMYIDA ATHAKNIIIM LDMSGSMLGQ
RFEIAKQTIE MILETLTEND FFNMIVFSEE PKFILSCFRN RLVQATIKNK KLMRVTLDNV
TAEGIANYPA ALSLAFEVLI EASQNPGVNS GCQNAIMLIT DGPSDTYEDI FEKYNKDKMI
RFFTYLIGDD VTETREVRWM ACYNRGYFAH ISNLADVQEK VQSYIGVMSR LTAERNRTDP
VWTGAYYDRL GAVLVATVAF PVVANDSFRG VVGASALITE LQQMAPLYML GTHSYTFIVD
NNGYVVHHPQ LRPLYMGKAK PHYNSMDIME MEVLADNYLE NGSLSNPVDY DSDLRRHLAD
GVSSKDFLRK FSQKIIWACD GSNNLRRVYL QNNVYYYRGI NNTLMSLALA VPEDSRYRIA
LPSTYSPYPF KNIDFKWFSG TNWRLHPDWH YCRINDSDYS MTKEEAFVIN MRHYSETGRI
ARNCALYTYL IERLLFDAEV TSQMDSAWIQ ESRLDERKGV HLVYLATHAG LTRFVSMDLK
DVQYQPDVQT WQSDDNRTEE LPVTLDKPYF HFSKRHTRAL DEVFYKRAMQ FLNGEFVFDV
NITNNIYLKN GSQTYPHAKD GRSIIVTGNR AILVRDDYGN EAPASVVGFE MLYASFEEMI
YNASHKMCHF NSKVRCYLLD EHGYIVYASL PHTSQERVHY LRQFFGHLSL ENTENGAIER
YLMKKLVDLF VYQKLLYVDF QDLCQNLNLY NSARRLFNPL LTVSKLIISM LQKMIRFFLE
INPLGIIFSL FSRYTTTFRD IQDGLPCDRA SSFYLLNNDF RGPLTLAEGK QLCSSVATSD
SYARVSSCNL YAYAVRIEKT NLVLVVYSTE GTQCNGDLCK DYFSRDSLPW GFSIALNATD
KVMHPQACKL TTRYRRPPSA CQAMEDDDPF AHCSGCSSQA SLLLVLLCVA VLFTECKSAH
RFDGECIFEF TILYLMQPEV DSVPSAEVVP SDRFWATMLT TLSGVSVEEL TSAIAKCKDL
VLQTAPMSAI RRELVRRLIE LRQKLHELKD GLTQDSKFDA TVMGHQFKTP SRTILERRYC
ECCGGLIWAF LQPWYFCRLC GFYVHVKCVK SVKRQCASLT VNENPVFELE ICPERGLAMQ
NFQCADCKTE VSIDSSLMVE ASQTARLCHY SGFYFCSVCH WNDEMVIPAR VIHNWDFTKY
TVSRCSRQFL RLMQKRPILR LEAMNSCLFK NIPQLQKIKS LRARLLLMKP YVMYCREAAS
QCLMTHLRPY AHFMEALDVY SIRDLIDINE TVLESRLMQA LEIFEKHIKN ECSICQGNGY
VCELCDNSEI LFPFDRSVGK CGQCSWIYHK SCFDKNNGIC PRCLRMSSRM AIRLLSKDSN
TRISSDKCSL SLHFISSHSM CFVELDLHPR YSSLDLLSAI DCLYRVLYLE KREESRRRMG
IWLSLQSKNE DQITNESTV
//
