ID A0A0V1MHU0_9BILA Unreviewed; 615 AA.
AC A0A0V1MHU0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Frizzled-10 {ECO:0000313|EMBL:KRZ71335.1};
GN Name=fzd10-a {ECO:0000313|EMBL:KRZ71335.1};
GN ORFNames=T10_12193 {ECO:0000313|EMBL:KRZ71335.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ71335.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ71335.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ71335.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ71335.1}.
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DR EMBL; JYDO01000098; KRZ71335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MHU0; -.
DR STRING; 268474.A0A0V1MHU0; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15909; 7tmF_FZD4_9_10-like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF23; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..615
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006882553"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..140
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 233..547
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 568..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 25..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 33..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 70..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 101..125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 615 AA; 68761 MW; ABD7E6E3E8D5B406 CRC64;
MRKLFYLIVV ICNLSICTMS AFRSCERITV PLCKDMPYNL TRLPNLMGDM DQNSVAQSLL
DFEPLVNIKC STNLRFFLCS VFTPMCTEAM DEPITSCRSV CQEVERSCAP LLSNFGLAWP
ALLNCSQFPA QNSEPPCMDP SPSKQKEDAL RKEKKLILQL KNSRTKLNLS KQTSAIDRMA
PSSELPTTAV AVATSISCGP QFVHIDRHEM QYHKCVLRCN QDWMFTEEQK NFAQVWMAVW
ASVCFLSTGF TVMTFLLDTS RFTYPKRPIV FIAICYCATS VGYLLRLLVG REAAGCQQLD
SGQSVLVSHS LSNAVCVVTF ILLYYFGLAS AVWWLILTMT WYLAAGRKWS QEAIARLSST
FHIIAWVIPA SLTVTLLVTH ELEASELTSM CFVCLHSSSA LFGFVVGPVA VFSAIGICFM
VAGIVSMVRI SREMRFRICD TDLQKLRKLM TKVCVFSLLY VVLTLIVVVC SVYEKFFDEE
WLSSQFECRP QSFKDATTGV GLRHCNMSGM GSLSPPAVEI YMLKVFISLT VGIISSMWIW
SKKTLLMWHH FFCEKLFSNP VAKSGPAQYA PGSSLQPSQD RVPSSALPSQ TAGTHYYFPA
GCPQPRGFCK SPAAH
//
