ID A0A0V1MPU8_9BILA Unreviewed; 1178 AA.
AC A0A0V1MPU8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=Msh6 {ECO:0000313|EMBL:KRZ73789.1};
GN ORFNames=T10_3496 {ECO:0000313|EMBL:KRZ73789.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ73789.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ73789.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ73789.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ73789.1}.
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DR EMBL; JYDO01000058; KRZ73789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MPU8; -.
DR STRING; 268474.A0A0V1MPU8; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 1042..1058
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 14..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 134202 MW; C58CE7365C45C5A3 CRC64;
MQSVGKQKTL FSFFGKLTPG SSKSAHPSSE KTAKEQKAVS NEELNCTNEE SPIKMLKNGQ
KRRLVIIESD SDSESETNIA KTNEPANEHG SPVSPVFPIS KRARLSVSGL NNLSTSTPKS
CEKTLEKFCY RSTISDQSIE VTTNEKHETS ECRFESTFEE STSYLNEKDN SYFSSFVADD
SFLKESTQQR FKHLDFEFLK PEKIRCPFCN LLDFDHNNIH VQYFCRDLNR RRPDDADYDA
RTLFVPESFL KEQTPAHRQW WLMKSKHFDT ILFFKVGKFY ELYHMDAVVG VKNLNLSFMK
GEYAHCGFPE VSFDRFSDQL IEHGFKIARV EQTETPEMLQ KRAHQELLPC KDKVIRREIC
RIITRGTKTY NFLDTEDDNV QVSYLAALCE QNSTDKKNQI GICFVNTSVG KISISQFEDD
CDYSQLRTLL ASYPPVQILF PRGQLSQHML NMFKYNLNNV DKEALIPKVQ FWTAADTLRH
LSLDCYFGVD DQGNVNWPEA LATCIDQQDL FQQTPKPQYA LGISSFGAVI WYLKECLIDH
DIIRLKNVEL YSPPTTMEIG KLASCHQPLK NRYMVLDDIT LRNLDIVNFE RKKSTKLTLY
DEINLCKTAM GKRLLHFWLC NPLCDLQEIE QRQTAVRNLI EQTELFESLI KQLREIPDLE
RLLQKMHSLS IKAPNTDHPE CRAVYFEADT YSKRKVADFV QLISGFSKAN KLMHTVCNFA
SEIHSSLLQM LFIRKGGCKC FPDIESDVQY FQNAFDHETA KTIGSIIPEK GVDPALDAAN
QTIVHAEEQL EKYLKTIQKR LNCSSVQYLS SGRNRYNLEI PESACKNLNH EFDFRSQRKG
FKRYTTKELD ELVKLLAASE ADREVALKDI MRRLFASFCE RKMKWYAAVE NIATLDVLLA
FAQYAKCSTR EVCCPKFVDA IDGKTFLRLD ESVHPCCGKI KTQGDYIAND VLIGSSESDT
GQVLLLTGAN MGGKSTLMRQ VGTLVVLAQI GSYVPARHFT LSPVDRIFTR IGARDSLITG
QSTLFVELRE TSAILKHATI HSFVIIDELG RGTSTWDGTA IAYATLQYIT NHIGCRTIFS
THYHSLIDSL AANPRIRLGH MACMVENEIE GADPTEENVV FLYKLAPGAC PKSYGFNAAK
LAGIHADVIK RAYAKSMYFA QMEKERVAQV KEAENAKV
//
