ID A0A0V1N3V5_9BILA Unreviewed; 655 AA.
AC A0A0V1N3V5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE SubName: Full=Calpain-5 {ECO:0000313|EMBL:KRZ78414.1};
GN Name=tra-3 {ECO:0000313|EMBL:KRZ78414.1};
GN ORFNames=T10_9761 {ECO:0000313|EMBL:KRZ78414.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ78414.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ78414.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ78414.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ78414.1}.
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DR EMBL; JYDO01000012; KRZ78414.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1N3V5; -.
DR STRING; 268474.A0A0V1N3V5; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF416; CALPAIN-5; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 24..346
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 506..623
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 250
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 287
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 655 AA; 74476 MW; 62F34BE6AC1D684B CRC64;
MAPEPFQNQR YKKLKKQLVK EGKLFTDLEF PPTNSSLYYD PKRNEGIEWK RPGDIVNNPK
LFVDGVSVND VTQGVLGNCW FVAACSALTR HKRFWTKVIP DANEQEWSSS RADKYCGIFH
FCFWRFGRWV DVVVDDLLPT RGGKLVYAQS KTRNEFWCAL LEKAFAKLNG CYESLSGGTL
AEAFVAITGG VPITIKLDSG IYYDHATARM ELFSMLKKAF NEKALMAVSI RANTLEEVEE
PLECGLLKGH SYAITEVKKL SLDSRYQSLF SSLFNTPEKV MMVRLQNPWG EKEWNGAWSD
GASEWDQISK EQQRELGLKI EENGEFWMCW EDICMHFTTI DLCYQFDTSV FSLSSRYHET
ILHGVWHCAN DKGDVLSDRA GGCANFKDSC LQNPQYRLDV LEDGGEFVAS LMQRGSGIRR
RQRTSYLTIG MILIKVEENR IYRLHKLTGQ IVAKSDYAGC ESVLMFAKNL RRGRYVIIPS
TFAPHEEGEF MLRLYATWNM QATELTLDGP APNPCSCLSK PFKCVTQLTV VGANNLHINN
NKGPINPYCV VKCDGREVRS LICKETRDPN WDLQCIFVRK SVDKPIQIDV WSSNMVRDAW
LGRILLQCPI NNGCSSGEQP LEAKAKKTAD VVTTADERQG KILYSVSTYD DPIRL
//
