ID A0A0V1P1G6_9BILA Unreviewed; 1871 AA.
AC A0A0V1P1G6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1F {ECO:0000313|EMBL:KRZ89963.1};
GN ORFNames=T08_7067 {ECO:0000313|EMBL:KRZ89963.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ89963.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ89963.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ89963.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ89963.1}.
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DR EMBL; JYDM01000062; KRZ89963.1; -; Genomic_DNA.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1093..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1174..1192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1204..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1292..1317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1454..1488
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 58..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1735..1759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..798
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 336
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 669
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1066
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1871 AA; 213134 MW; 29E33343AD08242E CRC64;
MIVRQVRHHA RSEANFNDDV NIGKELSGNE AAALLHGDEA RASRADLWQQ TLQAAVAAQT
ESSTTTKKRQ QQRKMQRNVQ QERPERSLLC LGLKNPIRKL FISIVEWKPF EWLILCMICA
NCIALAVYQP FPAHDSDRKN AVLEQVEYIF IVVFTIECVM KVIAYGFLFH PGAYLRNGWN
LLDFLIVVIG LISTALSTLN IHGFDVKALR AFRVLRPLRL VSGVPSLQVV LNSILRAMVP
LFHIALLVLF VIIIYAIIGL ELFCGKLHKT CVDQWTGEHV PDPGPCGESH TSFHCDRSKN
LVCTENHTWP GPNDGITNFD NFGLAMLTVF QCISLEGWTD VMYWVNDSVG REWPWIYFIT
LVILGSFFVL NLVLGVLSGE FSKEREKARA RGLFQKFREK QQLEDDLKGY LDWITQAEDI
DLVNEEDEEQ EAMDREEFGA DGEGGEEGGS KEEFQRQSWF SMKIKRLKKL NRRCRRSCRR
IVKSQAFYWL VIVLVFLNTM VLTSEHYGQP EWLDHFQEIA NLFFVVLFTL EMFLKMYSLG
FVNYFVALFN RFDCFVVIGS ILEFALTFAG LMKPLGVSVL RSARLLRIFK VTKYWNSLRN
LVASLLNSLR SIASLLLLLF LFIVIFALLG MQVFGGKFNT IDPNMNKPRA NFDTFVQALL
TVFQILTGED WNAVMYNGIA AFGGVHSIGV IVCIYFIVLF ICGNYILLNV FLAIAVDNLA
DAESLTAAEK EEENKRANEA DPEDDMVVKA TADEDAVSVG QFHESGEVKL PFNEPTDAED
EHLASGDDDQ EREMENQSQF KPTARPHRQS ELNLPKKTKP IPDASSLFLF SSTNKVRIFC
NKVINHSYFT NSVLVCILVS SAMLAAEDPL QASSFRNEVP KFVLNYFDYF FTTVFTIEIS
LKVLVYGLIL HKGSFCRNAF NLLDMLVVGV SLTSFGLKSG AISVVKILRV LRVLRPLRAI
NRAKGLKHVV QCVIVAVKTI GNIMLVTFML EFMFAIIGVQ IFKGSFFRCT DRARLTAEEC
KGTFIEFEGG DVTRPHVRNR EWTNYDFNFD NVQNAMVALF VVSTFEGWPD LLHVAMDSSD
EGIGPQYNAR VSVAIFFITF IVVIAFFMMN IFVGFVIVTF QSEGEREYEN CELDKNQRKC
IEFALTAKPQ RRYIPKNRFQ YKIWWFVTSQ PFEYAIFIII ILNTLILGMK HYKSSAAFDE
ALDVLNLFFT TVFALEFICK LFALTFKNYF GDAWNVFDFI IVLGSFIDII YGKVSVPTGE
AWQLIMLSCA NTPAAMCDPE SDDRGQPCGN DFAYPFFISF FMLCSFLIIN LFVAVIMDNF
DYLTRDWSIL GPHHLDEFVR LWSEYDPDAK GRIKHLDVVT LLRKISPPLG FGKLCPHRLA
CKRLVSMNMP LNSDGTVCFN STLFALVRTN LKIYTEVSSN IEEANEQLRA VIKRIWKRTP
QRLLDEIVPP SGRDDEITVG KFYATYLIQD YFRRFKKRKE VEQKETNMQG NITMSLQAGL
RTLHEIGPEI KRAISGNLET DWSKEFEEPQ HRRDHSLFGT LVHALQAHYK PFIEGNLTNP
AYSNVNGDLK SQEGFLNSNP TNLYATSRNG AVIHFSPTYV VEWTALVLFD SDHDSSEHEM
QERVRFVPRG SKPTGLSFEG SRWLPRKLSF RRTPIGGAAA VSNLQQGNNK RLQFSNAIIL
DDSDPDSVLH SENVVDLTES GDDSKLSVSP PLELRDDAYY LDGIDYNTWR PAPMGQGVRL
RGRGNGRRKS RSMPLPHHEH QRNYADVLVE KVLADQGLGR YADPNLIRTT QLEIAEAYNM
TEAQMHSAAR SLMQRSPKYF EHMGGQRPAD IKDFNQYSKT ALLKPREINS SEEVDISDDM
NMFMSVSHII N
//
