ID A0A0V1P4B2_9BILA Unreviewed; 1246 AA.
AC A0A0V1P4B2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Exosome component 10 {ECO:0000313|EMBL:KRZ90939.1};
GN Name=Exosc10 {ECO:0000313|EMBL:KRZ90939.1};
GN ORFNames=T08_16345 {ECO:0000313|EMBL:KRZ90939.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ90939.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ90939.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ90939.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ90939.1}.
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DR EMBL; JYDM01000050; KRZ90939.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1P4B2; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..349
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 851..931
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1081..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 142281 MW; 38823E4C517C4979 CRC64;
MPIAIVELAE EMKYGIYQQG WVLSAFSAGY IGSQILSSCI GAQWNSYGLL GFVVLLWSIS
MLVTPYVASS FPLLMFSRLL LGLGEGLGLP TIYKLFAEDV PSEKRSTAFS CLSSFASIGQ
TMALVCCPHL HWRWPFYLFG MVGIVWCIAW WRFLRYAPIL PFEQTSHVLK SFNLMKSWRI
FFCSSQLLCV YVAHFCMNWT SYIIMHWLPV YLRVGPVADW LINKRKLRVV RVRQLCTVIG
LAVPAVFLIC FSVLDHVGLS LLVVSLCMGF LAFNSAGHLS SHADLCRTYA GVSFAISNTL
ATLPGLVVGP LTADFVMQSS GRWGPVFILA AMLNLVGSVI YLNYSSTKRN EYFLKVISNS
FDIFYLSMAF GERMNADKED GDQSLSDLEE DESIVEQLRV AVANLLKKCS LFRVGDQHLL
AGDLKMLLVK ASVQLLDLLN EAITYISETF PKIPNGAHHT MMMNEIAKIN DILDERITSS
FDEVRGTSGE YLQDLRIERN AVEVATASWN CISVPSKEAV ETERAVENFS EEMHFNNKRR
FIPKPQLNFR DQIDNTLNPF KTKLRIKHHE ISPEKLSNVK LFIQREQQLA NNAEMEYFSE
PAHPYYYEII TCEPNSLMLS IKEPQHPIMP LNACKLVFVR SKKFLQSLVN DLNSQQAFAV
DLEHNSYRSY YGLTCLLQIS TRDTDYIVDP FPIWHEMYIL NEPFVDPNIV KVMHGSSQDI
QWLQRDFGIY VVNLFDTYHA MEVLEMPQRS LKFLVKELVG VKLDKSYQTA DWRIRPLGSK
MLAYARSDSH YLLYCWDVLR NELLNRGNEY NDLMMIVLKR SNDTCLQVYK KKFPNEFELK
KLESKFPFNL DNRQKYALRM LYYWRDGVAR ITDESVYYIM RNDTLRNLAA KLPRDMQLLE
NACKPITGAL MPHLHEIQKI ICDAWCLDLF TMKSPKAETV AVERSSVARR RPHDIYIDEN
KKELPLSQIF DRPVDETVKQ SMPNSESFKA SSGETFHHVL LTSQSDSAKS GTEKDEKAEL
LLLDDFAVFE KYCLTKEIRD VNKPEPARIV WDVGYNDEQR KAAEEESEVC DEVIKIQSAA
PAYSGGKTQE PNKMTDTQHN SSSLSIEKPN ETLKAFYKPY DYSNSAVRCF RGGSSTEGDS
TEARGTVSAS QSAVTAIVLM TWQQDRICFS SKIAGHSSVA KVSQILLKKQ SPKMNDNVKS
RKLIFLIFHV LSYASFLVRR RYVHLVYVLD GYEVSRSAGA VGETHR
//
