ID A0A0W0SSK1_9GAMM Unreviewed; 889 AA.
AC A0A0W0SSK1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=Lbru_0838 {ECO:0000313|EMBL:KTC86344.1};
OS Legionella brunensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=29422 {ECO:0000313|EMBL:KTC86344.1, ECO:0000313|Proteomes:UP000054742};
RN [1] {ECO:0000313|EMBL:KTC86344.1, ECO:0000313|Proteomes:UP000054742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43878 {ECO:0000313|EMBL:KTC86344.1,
RC ECO:0000313|Proteomes:UP000054742};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTC86344.1}.
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DR EMBL; LNXV01000005; KTC86344.1; -; Genomic_DNA.
DR RefSeq; WP_058440935.1; NZ_LNXV01000005.1.
DR AlphaFoldDB; A0A0W0SSK1; -.
DR STRING; 29422.Lbru_0838; -.
DR PATRIC; fig|29422.6.peg.878; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000054742; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:KTC86344.1};
KW Ion transport {ECO:0000313|EMBL:KTC86344.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KTC86344.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KTC86344.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:KTC86344.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 673..880
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 889 AA; 100091 MW; EC476D1527721BE9 CRC64;
MVGIDDQRPD PDILLAKVQS QEKLASQGRL RIYFGASAGV GKTYAMLTEA RKLKLEGYDV
VVGLVETHGR KETDALLLDL PILTRKAIHY RGKEIFEFDI DAALARKPDL ILVDELAHSN
IPGTRHPKRW QDIEELLEAD IDVFTTLNVQ HLESLNDVIG DITNIHISET VPDTIFDKAD
EVVIVDITAD DLLLRLKEGK VYQGAQGELA AKNFFRKGNL IALRELALRR TAERIEEDVQ
AYRVEQSINE VWKTDTALLA CVGERPGAEY VIRNTARLAN QLNADWHAIY VETHQLMHLP
FSKRQYALKA LKLAEELGAT TSILTGEDIL LTIVDYARNQ NFSKIVFGRR SHSFRFWRRS
LLSRMANFAP DLDLLVVGNI KDTETGKVKE VDYEVQKQKK GYQHYLMVIG LSLLTILVVK
LFESLLNMVN IGLLFLLMLL LIAIRFGRGP SVVASLVAVC GLDFFFVTPR YSSLIADRQY
LIMLILMFII VVTTGYLTSN LRYQIFAAGQ RESQTHRLYQ FSRELLSALQ TEPILETTRM
YILHAFNARA WLLLPDDADR LKPLSSNSNM QDFDMGIAQW AFDHKEAAGY GTDTLPGNSF
FYLPLVAPMR TRGLLIIKPK NRHWMKTPEE RQQLDTFAAL AALALERVHF IQVAQDALVH
MESERIRNAL LAGLSHDLKT PMASMLNLSK SLVKSDSALT PLQKKLAQSL KEEILHMERL
INNLLEMARI KSGELKLNLQ WRHFEEIIVN AMRVINAKIT THPIDTLLEE DLPLIYLDAV
LMEKVLSTLL ERACKYTPKG TSIILEAAIS QDNLCINIYD KALTLSAGQA KAIAHFKHDF
RIDLEVAIAG AIIEAHGGKI HLGHSPMGGT SIICSIPLKP STDLIVSDA
//
