ID A0A0W0THS0_9GAMM Unreviewed; 528 AA.
AC A0A0W0THS0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Calpain family cysteine protease {ECO:0000313|EMBL:KTC95151.1};
GN ORFNames=Lfee_2815 {ECO:0000313|EMBL:KTC95151.1}, NCTC12022_03252
GN {ECO:0000313|EMBL:SPX62491.1};
OS Legionella feeleii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=453 {ECO:0000313|EMBL:KTC95151.1, ECO:0000313|Proteomes:UP000054698};
RN [1] {ECO:0000313|EMBL:KTC95151.1, ECO:0000313|Proteomes:UP000054698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-44C {ECO:0000313|EMBL:KTC95151.1,
RC ECO:0000313|Proteomes:UP000054698};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPX62491.1, ECO:0000313|Proteomes:UP000251942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12022 {ECO:0000313|EMBL:SPX62491.1,
RC ECO:0000313|Proteomes:UP000251942};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LNYB01000085; KTC95151.1; -; Genomic_DNA.
DR EMBL; UASS01000038; SPX62491.1; -; Genomic_DNA.
DR RefSeq; WP_058447630.1; NZ_UASS01000038.1.
DR AlphaFoldDB; A0A0W0THS0; -.
DR STRING; 453.Lfee_2815; -.
DR PATRIC; fig|453.4.peg.3077; -.
DR OrthoDB; 5643665at2; -.
DR Proteomes; UP000054698; Unassembled WGS sequence.
DR Proteomes; UP000251942; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Protease {ECO:0000256|PROSITE-ProRule:PRU00239,
KW ECO:0000313|EMBL:KTC95151.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054698};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 52..511
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 528 AA; 61140 MW; 19CB128F38D1D2B8 CRC64;
MLTNNEVIAP IFNISAEDEQ DLWGADKTIW FKKLSTKELQ ELVNTDHYEL KDIAQGGIGN
CYFLAALSAI VDRDPGLLEN MITLGRDREG NLRVNVTLYA EDGSPRIYSM PPTVTRGYTE
GTVNYHKKPW VEILEKAYTF HRLTHLKSKP TQEEFERAQS LLKQDESDWS EDDTKLIKRY
RETREYLASL SSGSPAEVFK TLLGTSATRE KLGQHSLLTD AFCLLNDAYD VVADERQLRN
LKMSIKECFR NAFGFEELNN DWLEQKALQL VAHFKERERL SPKRKIYCHE LEPLIEWLEV
CINELKQMAT EQLPEQYLLG EQTLNSLKLF LQQDNFPIRS PLSLKEFHVV FLINNLLANN
QFITLSTGPR KDYQNHPLSR VIAMSEDSGH SYQCLGLWLE GDELFLHLRN PWGKGQIDYK
RDMVGNLLRN EDGELLPFII PEKKKHSSFM SFFEGLVIGE IDDMEEPERM NLFVNLSDEK
MQEQQESGGV FYLSLHDVAR YFTDVDFTNE PEGFPYSETA QPKISFEQ
//
