ID A0A0W0VU76_9GAMM Unreviewed; 558 AA.
AC A0A0W0VU76;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Serine metalloprotease {ECO:0000313|EMBL:KTD23751.1};
GN ORFNames=Llan_0532 {ECO:0000313|EMBL:KTD23751.1};
OS Legionella lansingensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=45067 {ECO:0000313|EMBL:KTD23751.1, ECO:0000313|Proteomes:UP000054869};
RN [1] {ECO:0000313|EMBL:KTD23751.1, ECO:0000313|Proteomes:UP000054869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49751 {ECO:0000313|EMBL:KTD23751.1,
RC ECO:0000313|Proteomes:UP000054869};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD23751.1}.
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DR EMBL; LNYI01000011; KTD23751.1; -; Genomic_DNA.
DR RefSeq; WP_028372247.1; NZ_LT906451.1.
DR AlphaFoldDB; A0A0W0VU76; -.
DR STRING; 45067.Llan_0532; -.
DR PATRIC; fig|45067.4.peg.558; -.
DR eggNOG; COG1404; Bacteria.
DR OrthoDB; 9790784at2; -.
DR Proteomes; UP000054869; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Metalloprotease {ECO:0000313|EMBL:KTD23751.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000054869};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..558
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006915075"
FT DOMAIN 162..429
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 169
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 210
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 394
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 558 AA; 59838 MW; 7E7FBDF57BA2EA57 CRC64;
MHCKSGVVGL TFLILGQAAM ANDDTIRVIV KYKEPVSTLT ALQTQLSKST HLAIQALTPM
AGGAYVVSFS IRGAQQSKNG VSTLDSVLQD LRKNEHVAYA VEDRVGRIQP LPTLKIEDLA
DKLLSHDTQW DEFAAPGGIM LESAPYRHDG AWAHTTGKSA KPIVIAVLDT GVALNDSLVN
NLVKDKQDNV WGWNFAANNR DISDETASYH GTHVAGTIAG YGDVMLGVGE DLKILPVKIP
DGSGMFYESQ VINAIYWSVG GEVPGVPNNP YPAKVLNMSF GVDERPGKEI DHCDEALQEA
LFYAREQGAV IAVAAGNDNR WEHYNAPAVC NGTIKVASTG PAGLRAYYSN YGPTVSFAAP
GGDLRYGRKG GILSTVNPGG GYLNSGFDFY QGTSMASPHV AGVAGLIFAV RDGRISPESV
EQILYATTHA FGKTADENKS CVGKKPCGHG ILDAENAIKA TMADYDLIIS APRITQLPKE
PCRQKGAQSV ITVEQAGQEV RWITSKTFCG GDVIVKPVQL TTKTGQIIAD YGVMSYRLDD
TRFKRCEIIG FDGIGCYL
//
