ID A0A0W0ZZK5_9GAMM Unreviewed; 747 AA.
AC A0A0W0ZZK5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Adenylate/guanylate cyclase transmembrane protein {ECO:0000313|EMBL:KTD74542.1};
GN ORFNames=Ltuc_2389 {ECO:0000313|EMBL:KTD74542.1};
OS Legionella tucsonensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=40335 {ECO:0000313|EMBL:KTD74542.1, ECO:0000313|Proteomes:UP000054693};
RN [1] {ECO:0000313|EMBL:KTD74542.1, ECO:0000313|Proteomes:UP000054693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49180 {ECO:0000313|EMBL:KTD74542.1,
RC ECO:0000313|Proteomes:UP000054693};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD74542.1}.
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DR EMBL; LNZA01000001; KTD74542.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0ZZK5; -.
DR STRING; 40335.Ltuc_2389; -.
DR PATRIC; fig|40335.7.peg.2547; -.
DR Proteomes; UP000054693; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR007890; CHASE2.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF05226; CHASE2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM01080; CHASE2; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054693};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:KTD74542.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 492..624
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 747 AA; 84988 MW; 9AB45FDC62978525 CRC64;
MKKERYFSPK SIRSKGTQVL LGLFWSALIF LADVTHIPLL SSFITQLDYR TYDQVVQLNL
RPHQTIPRIV IIDIDNKSVE QEGRWPWPRN KMAALINKLK QNGVVTIATD IVMAEAEVNY
AIGLKDELQK LMPQLPAGQK QLPGLLKQIA PKVDNDRILA ESLLDHNVVL GFLFHNDKEI
RKGELPSPLT NPEENYLYRD NLPLHQFSGY NGCLPLFLKA STQAGAVTNV PDLDGTIRHG
LMLASYNNKL YATLALATAM NYLMVKHITL KTHHHQLYGI QMGNVFIPTN AYGQILIPFW
GQIGSQDYYS ATDIIRDKVN PKQLQGAIAV IGSTIILLAD LHQSPVAQSY PGVEMVGNMV
QGIVGQQLVS EYNWKTPKAR LYLILIGVFF TFIFSILSVS RILILAMINI IGIWALSIYL
FVYKSLYLPI ALILTLIVLL TVTNYAYLFI IERRQKRKIN QLFGQYVPED YVKELIESPD
QYSMEGQERN MTVLFSDIRN FTDLSESLDA THVKRLLNAF FTPITEIIFS FRGTIDKYVG
DMIVAFWGAP MQDEEHASHA IMCSLTMAKQ LPEINEKMQE KNLPAVNFGI GLATGLMNVG
DMGSEFRRAY TVIGDTVNLA SRLQDLTKFY QVTILVSDKT HAGQDQFVWR TIDKITVKGR
KSGLTIYQPL GKDSEVSEEV LTQLEEYHKA LEEYYAQNWS SAGKKFAMLK TKFPNVYLYQ
MYLERVKTFK ETPPPENWDG IYMHQHK
//
