ID A0A0W8CGG8_PHYNI Unreviewed; 351 AA.
AC A0A0W8CGG8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Imidazoleglycerol-phosphate dehydratase {ECO:0000256|ARBA:ARBA00012075, ECO:0000256|RuleBase:RU000598};
DE EC=4.2.1.19 {ECO:0000256|ARBA:ARBA00012075, ECO:0000256|RuleBase:RU000598};
GN ORFNames=AM587_10000024 {ECO:0000313|EMBL:KUF83076.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF83076.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF83076.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-
CC 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
CC Evidence={ECO:0000256|ARBA:ARBA00001723,
CC ECO:0000256|RuleBase:RU000598};
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC {ECO:0000256|ARBA:ARBA00005047, ECO:0000256|RuleBase:RU000598}.
CC -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007481, ECO:0000256|RuleBase:RU000598}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF83076.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LNFO01003376; KUF83076.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8CGG8; -.
DR EnsemblProtists; KUF83076; KUF83076; AM587_10000024.
DR OMA; LWARAPY; -.
DR UniPathway; UPA00031; UER00011.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd07914; IGPD; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR HAMAP; MF_00076; HisB; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR041492; HAD_2.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR038494; IGPD_sf.
DR InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR NCBIfam; TIGR01549; HAD-SF-IA-v1; 1.
DR PANTHER; PTHR23133:SF2; IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE; 1.
DR PANTHER; PTHR23133; IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7; 1.
DR Pfam; PF13419; HAD_2; 1.
DR Pfam; PF00475; IGPD; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 2.
DR PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102,
KW ECO:0000256|RuleBase:RU000598};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000598};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943}.
SQ SEQUENCE 351 AA; 37072 MW; C667618F38CF384E CRC64;
MAVVTGRPRK DCAKFLTTHG IEDLFPVQIC MEDCPPKPSP EPILLALKAL GVEACHAAMV
GDTVDDIIAG RKAGAVAYGV LTPQTYAKSI LEQTPAAIGK VLEQVGASVV LTPGLGELLD
LVPAVPTASK APTVNGKSGV REANISRVTK ETSISVKLSL DGTGKSKVSS GIGFLDHMLT
ALAKHSRFDL ELDCKGDTWI DDHHTTEDCA LTLGEAFDVA LGDRAGIARF GSACVPLDEA
LSRAIVDISS RAHSEINLQL VRPSVGELSC EMITHFFESF ASAARLTLHV DVLRGRNDHH
RAEASFKALA VALRTAVKHD ATAGVPSTKG VLAXAKHRSG VLTRHMLSVS K
//
