ID A0A0W8CVZ1_PHYNI Unreviewed; 4296 AA.
AC A0A0W8CVZ1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=E3 ubiquitin-protein ligase HERC1 {ECO:0000313|EMBL:KUF88166.1};
GN ORFNames=AM587_10016591 {ECO:0000313|EMBL:KUF88166.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF88166.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF88166.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF88166.1}.
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DR EMBL; LNFO01001893; KUF88166.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8CVZ1; -.
DR EnsemblProtists; KUF88166; KUF88166; AM587_10016591.
DR OMA; MTEIFRC; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd11709; SPRY; 2.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR22870:SF463; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 6.
DR Pfam; PF00622; SPRY; 2.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00449; SPRY; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 7.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 296..358
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 359..411
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 412..481
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 482..537
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 538..599
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 600..651
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 652..705
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 2467..2660
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3338..3529
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 4128..4296
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2701..2766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3324..3349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3989..4018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2712..2740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2742..2766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3324..3340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3994..4016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4296 AA; 477029 MW; DC900A57D75D2739 CRC64;
MEALLLQDGA YVNDRYEELQ GQRRQLDQIG PVKPIGDVAG CSSTSELSYE ERQQLEHWRI
VQRAKALDAK GPTPQLNKKF LVLQNILEKL YAEKEADLYI TSPPNGALKR PDPTDTNTPV
PFKELPLPTQ VVLKMFFRTC QSLRDPTKLA AYSRLSVQIA AKLPGILTTM PSCVLSPGLA
DDVPVDLEDR GNIWSVFYQL FQLFEELLEL KNDSVGGERV CLSASDRATV IVAYVALCLK
WGRLSYLLKG IKLLLENDAE LSGVRLEPLQ PLFHELASAS AERPQVANGE EDQPSGYLMS
FGKGDHGKLG HGQCVHVSCQ EGNCTENKTV PTMIAATRDV LFRKIDSLST HSIAITAKGD
AMSWGNGDKY RLGHGSSTKE YAPRTIEFLR LKGRVRDLAC GLGHTLALME SGELFAWGNG
SNGRLGLGDS NDRSSPARVT IPTASQGNAV EGEPESSFTS APIRFRHIYC GASHSLGLSW
DGRAYAWGKN NQGQCGHGHT NDQWTIQEIE NFEDGGEEES VAYAAGGWEH TLFCTASGRV
YSCGCGYKDS RRAGIPPVLG HGDCDRRLRP TLIQTLDDAR EEIVKVACGW DHSLAVSASG
KVYTWGSGTN GKLGHGDEES FDIPTLVRSM ESKHVKDAKA GCEHTVFLTY DQELWTCGQG
DSGRLGHGDS QTRKRPTKIE LFGECGLKPV ALAVGDKYNL VLVRDSDAQY ECEDDNEPAS
IPKTQQRGSN EVPNHGIRLQ HGRHRTGQHK KHNANSGNEF GANWVLSVAE GMTPKEISPT
TPLNAPDSVS NAALFIAGHV DRLASDYISE ESETLVEKSN EQKVMETNVK APRSTLIPFA
VDTSYESLNA LLDLLQWATS LVGSKEKAAG SGSTCLRTLE RMGLALSCLR ILQLNLKKSL
NVLRLSADNV REHFSLSKDL FGRVHALLDS LAGLKKEDCV ERFDIGAHRS SDGQKLSAIG
SAISHEAACA LKDTIMTEIF RCLPTHGLLR NVLHDDHKGV PDKDMLDIKT LMILLLRRSS
AEAIKHLDNE SFTDFTNEPD CFLRLLHVLQ IHYFSIVHRS AVTKTDISND PGLIQSNTNR
QMLDSLLEYM DALMAESLTV LKRLHISSRQ HEEIITWRLN GSFFHTLLPS AIECLSILVL
PTPNREYTSN AKTVDNLVLV ERILPNLHVM LKMLDEVSWK MHTATDAGNQ AHDDTTTPTR
QLGFTVQNRN WFVDLGDACA TLCGKLSCEL FYPWRTVNMG SDDTEVGNYY SHVLSEGQLL
RENQDVLPTI RANESSSIRN ILDWERLGVF EVEDELVGGK EDSTATGSVV SSALESQRFL
LQLCDTDFSS NRLSFWNWVA GKLSQVVEFK SEAQKVLLLV LSISSWHLGL SSELRSVYEM
YDAAAQNSVA IDPVVPTGKI WEMLSVLISG TKWESWVYNA LDSEAVGNAI KLSRLLLSLQ
PNPALTPRIL RCEAGVEHPD LSECIDDSLV EMLEFLTTIH DVDTIQHSLE MKEEEAALLR
TGICVLHDLL RKLTTSSTKS CLLDEFVAVT CGTNXANLIK RIILIGQHGK HIDKAIENLF
VRLARVVSNE EASFELKKMA LMAWTVPLSD SKRGVPRVVD LIANSGIMST LVELLLDEAN
VLDVHSDINA NTHLRATDNH NDKRFGSAQD ESKLSTKMSP IKALLFDQTP AQIISILAWE
AFCAIAMQLS KSEHFAEHRS SLLLRSAGSS LHDKEPLTPR SSVMSPRRRL TLPKKVIISS
IDEIIEQMAD GLFSMLEGLK NRLDTLDISS QDYGALIKQM EKGSGSTEKH DYSRVCQFGS
PVQLSHSNSY DISIPKVNTK ASEGTTSVTV SFWLHVEHTG ATISNNEVSA PSSPSGSKVT
SVRLITFSTS QATSESTDTD RDGSLVVFIR DMNPDHVCIR LSLKCEEDTN ERWRSILVDE
RIPRGKWAQI VLAFDKERPE HLHAYIGARC STLNNSQQSG DRCKSFCLEI LQKATSWTQM
TVGGIADVDA LTYVKETNTP ELRLPVLPKR PMHGFTAVLD DVVLSREALS EEKIARMQHS
GPILFRLKQQ YIAESQCVKV LRLLCQLVAE EETSRDGSPA KIPSSDRWII LFTHMLLSSC
RDQNLAQVYL CHLLEDVLPR ASPPPECDIQ ILGHKLFGPR QKTTMSLEDL FIELNENTHL
PSNSTIRRQN EALYRTMHQR GILHGKYRGG SSSENVQQYD ETNTDKLALN TKVSMRFAAA
VHLFQKLCSS PLWGSRMDCF IERPCAIFQS GGGLHEMLES EESSSIQLAD MTAVVSAIAG
YSEQVVNSHR ASVQNAAIPS SAIQTCSSPF DSVVRFDKYS DDHIRKTQDL IAAMMREETG
NALQLSARKD ILAKCHNDIV AVNAIDQRIC TVVHQRARVL RVLTTALLRE KITTTSGLWH
DFLLNNTTVC DDLLQLASSS LKEQVVTVLG PDAKIAMKLR RLRIFFKEVV RGGRHHRDAP
LTISLADLEK IQWRLWEEFA TRSSISLLPW WQNSESDSKL TLEVVGGDVE LNGFKVTALE
HFPTVRLAQA SITASSGLWF FEVVVLTDGL MQIGYVDGDF TADPLQGQGV GDHTNSWAYD
GFRCKKWNVN SYDYGEQWKT DDVVGVLLDT DRMELSYFLN GKFLGVAFSG IPITSSSRMC
PAASLNVQQS AEFHFGTLNV ASSSESTSVG GFKYLPVLDN DDQTRVRPII AALGTANVDN
SGKEEVKEND TSDWSNSSSD TDEGEITLEG SDSLSSFRRT LDLGSRDGRE TRTADQNDEE
SGHRRRDLIE GLTGLGFPLE WATRCATESR MPMDETGAVA WILEQMEKEI GPDVASRLPA
TSGFNDGMIH LPNLAVSHST DDFATEAGEI LSSSALDDKI LNIPAFRSSR SLLAGNLGIT
SAGINAFIEA DKDDQQSDDI TSEAFQSDLY RQRQIGLQTL SDVGTISEGN KRGVDDLLPL
SIVVDTTVFV AYSRQAFTSL LLLALKKEGQ EAVYRMVQPL ISTEETSARL RHFLKIGIGL
DTMDTVFELD FISANFESEQ SLRLQKAVAA LLRYEGTLSV ESPTGECSPF LRFFYQEMLS
QCDRGLSLTR NKQSSKSVSD TRSIQADAAW FAWVSGAVIG FVEAPAWAVS EVKDEAQNSD
FVAPLFSNSA FAEKLVSIAS SSSTTLKAWK YVAFRLMTRI LYVIRARDNS SEFLASTHLT
NLMELFTLRC RREMHSRVFY SDVTNALFAL LVHSAANVTL NQDKIRQSEN QSLSLRVSNY
SSTHVTISWD QASVASPSDF DSLTDTSTTE NKAENYSGVI ILHVTRADSE KPFDISKALP
SKGSYTIRNL LPDTQYRISL DPAQTVSDDP TCATDESKAD GSNDVGTEVM VQTPPEPLFE
LDRETLGKNL VIFNQNLTAK NTVNKKWHSV RASVAFEEGI HSWQVRLDTC VSKNIFIGVC
TADASMENYV GSDAYGYGFL ANKAIWHNKA KLHSYGEIFK QGDIIQVTLD CNAKTLAFSR
NGEYLGIAAT NMRAGTNRSD GEGNYKWYPA VSMYNKDDKV TLIPPPAATL FSIKEGRPQN
ASTLELIETM QMVLAYQSHV TGMNMSSTNF FENAFEEFDS WRREEILFRE TALGQVIAIS
KSKSATEKYG LAFGDTVFTS KGQCSVLGEY RHELWYEIDE GGSSVLYRTS CTSQLASWSL
STCREMLESP DEYPVHRHHK YKVELETSEA NCAADHQDSS ADTTEQEEFS LKSFVDAQME
WSESGVAAEA DSKLLAELDA IASSQGSSSA LSLTIEDIST ALILEKLCRG HGIGAEDRSK
QTIARIGLLL YTNRCLYKVA RLAIPRNIFA TTLGILEISE RFTKSKNSRK EEPTVCTEYL
QVSPIAALLN SPQWTLDDPS AFAQISILAA RLLFSSQKEK LTEEELDRTK TTSRTLDSLQ
ESNDNENVDM DLPVIKINYP VSGEVPFWEC SPAILKKKKR FCLPTSTESS VFAQLIKQLS
AQESRQWRRS SSQPFEAIPI SQTFQVQIEK QSTESGEVGK HELHQQQDED EDEQLQQPSS
KQTAMYLNLF ENAVREIQSP SFPLFTPVQG QKLGETRQSL QLDVNLYLFS SSALAHSRLQ
SSQLLLWYFC IGQILGIAWR SKLLLPLQFL SKSFWEELVS PAGRHKDEGS RSIVREAAVR
AIRDGLFSII PSRCVALLSG TNPSLREHLS DLDINYVVRL ERHAIYLVSR QNHHDLFWKV
VNAFTSVERR MLEQFINSER RHSFKQVEVT QDTDNSSNFV LELADALADG RDHPDSCYPV
VVSTGLHSSR LHLPAYTSAH TLRQKLLLAM TNIPFV
//
