ID   A0A0X3RWL7_9ACTN        Unreviewed;       841 AA.
AC   A0A0X3RWL7;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=NDP-hexose 4-ketoreductase {ECO:0000313|EMBL:KUJ35406.1};
GN   ORFNames=ADL25_36995 {ECO:0000313|EMBL:KUJ35406.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ35406.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUJ35406.1}.
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DR   EMBL; LMWH01000268; KUJ35406.1; -; Genomic_DNA.
DR   RefSeq; WP_059132311.1; NZ_LMWH01000268.1.
DR   AlphaFoldDB; A0A0X3RWL7; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}.
FT   DOMAIN          2..144
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   DOMAIN          421..456
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   REGION          814..841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   841 AA;  92825 MW;  65024C0AF2F4F37D CRC64;
     MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKALE SLGISLEAVR
     QQVEEIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH NYIGTEHILL GLIREGEGVA
     AQVLVKLGAD LNRVRQQVIQ LLSGYQGKET ATAGGPAEGT PSTSLVLDQF GRNLTQAARE
     SKLDPVIGRE KEIERVMQVL SRRTKNNPVL IGEPGVGKTA VVEGLAQAIV KGEVPETLKD
     KHLYTLDLGA LVAGSRYRGD FEERLKKVLK EIRTRGDIIL FIDELHTLVG AGAAEGAIDA
     ASILKPMLAR GELQTIGATT LDEYRKHLEK DAALERRFQP IQVAEPSLPH TIEILKGLRD
     RYEAHHRVSI TDEALVQAAT LADRYISDRF LPDKAIDLID EAGSRMRIRR MTAPPDLREF
     DEKIAGVRRD KESAIDSQDF EKAASLRDKE KQLLAAKAKR EKEWKAGDMD VVAEVDGELI
     AEVLATATGI PVFKLTEEES SRLLRMEDEL HKRVIGQVDA VKALSKAIRR TRAGLKDPKR
     PGGSFIFAGP SGVGKTELSK ALAEFLFGDE DALISLDMSE FSEKHTVSRL FGSPPGYVGY
     EEGGQLTEKV RRKPFSVVLF DEVEKAHPDI FNSLLQILED GRLTDSQGRV VDFKNTVIIM
     TTNLGTRDIS KGFNLGFAAA GDTKTNYERM KNKVSDELKQ HFRPEFLNRV DDVVVFPQLT
     QADILAIVDL MIGKVDERLK DRDMGLELAQ SAKELLAKKG YDPVLGARPL RRTIQREIED
     TLSEKILFGE LRPGHIVVVD TEGEGDTQTF TFRGEEKSAL PDVPPIEQAA GGAGPNLSKE
     A
//