ID A0A0X3SJN9_9ACTN Unreviewed; 320 AA.
AC A0A0X3SJN9;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:KUJ43687.1};
GN ORFNames=ADL25_12065 {ECO:0000313|EMBL:KUJ43687.1};
OS Streptomyces sp. NRRL F-5122.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ43687.1, ECO:0000313|Proteomes:UP000054048};
RN [1] {ECO:0000313|Proteomes:UP000054048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ43687.1}.
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DR EMBL; LMWH01000093; KUJ43687.1; -; Genomic_DNA.
DR RefSeq; WP_059127688.1; NZ_LMWH01000093.1.
DR AlphaFoldDB; A0A0X3SJN9; -.
DR OrthoDB; 4324715at2; -.
DR Proteomes; UP000054048; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:UniProt.
DR CDD; cd05300; 2-Hacid_dh_1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT DOMAIN 112..279
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 320 AA; 35054 MW; CEB3E4F9F2E26D3F CRC64;
MTARPPGRPT LLVLDAEPLP RLGRLTGRVR IEHVDDSALA RRLPYADVLL VWDFTSRAVR
DAWPGEGPRP RWVHAASAGV DHLLCPELAA SDAVVTNARG VFERPVAEYV AALVLAMAKD
LPRTWDLQRE RRWRHRETTR VAGTRACVVG SGPIGRTIAR TLKALEVTTS IVGRVPRTGI
HGPADLDRLM ARADWVVAAA PLTEQTQGMF DARRFGVMQP SARFVNVGRG GLVVEGALTE
ALTKRWIAGA ALDVFQNEPL APDSPLWHVP GLLVSPHMSG DTVGWRDELG AQFVGLYERW
EAGKPLVNVV DKKRGYVPGH
//
