ID A0A0X3UWM3_9ACTN Unreviewed; 445 AA.
AC A0A0X3UWM3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:KUL36242.1};
GN ORFNames=ADL22_25340 {ECO:0000313|EMBL:KUL36242.1};
OS Streptomyces sp. NRRL F-4489.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL36242.1, ECO:0000313|Proteomes:UP000053256};
RN [1] {ECO:0000313|EMBL:KUL36242.1, ECO:0000313|Proteomes:UP000053256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL36242.1,
RC ECO:0000313|Proteomes:UP000053256};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL36242.1}.
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DR EMBL; LLZI01000251; KUL36242.1; -; Genomic_DNA.
DR RefSeq; WP_066984275.1; NZ_LLZI01000251.1.
DR AlphaFoldDB; A0A0X3UWM3; -.
DR STRING; 1609095.ADL22_25340; -.
DR OrthoDB; 5242012at2; -.
DR Proteomes; UP000053256; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR025828; Put_sensor_dom.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13796; Sensor; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KUL36242.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053256};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 39..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..229
FT /note="Putative sensor"
FT /evidence="ECO:0000259|Pfam:PF13796"
FT DOMAIN 257..321
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 46766 MW; F316C562C174D831 CRC64;
MDTAYSAHPH PAPGPRARGR RRVPAGLAAP FSGRTWREFL YLCLSLPVAC LMFAYAVTLV
SVSAGLLITF VGIPVLAGGL AGARGLGAVE RARARALLGL EVAGPRPLRP ARPGPVAWTV
ALLRSGASWR HLLYAFVHFP WALGAFVLAV TWWSVGWAML TFPLWFRFVP AYAGLPRLQL
WGDDGTVLYV SPGVAAGVTG GVGLLLVLAG PWLFRGLTAV DRLLVRGLLG TSPLAARVSE
LESDRGVLAD TAATDLRRIE RELHDGAQAR LAALALDLGL AKEKLAEDPH AAARMVDAAH
GEVKIALQEL RDLARGIHPA ILTDRGLGPA LTSLAGRCPV PVAVRVDLAE RPAAAIEGIA
YFTVAELLRN VARHSGADRA TVDVWRSGDQ LLVMVADDGQ GGADPESGGG LADLAARLDS
VDGLLVVDSP PGGPTAVTAE LPWRG
//
