ID A0A0X3W234_9ACTN Unreviewed; 483 AA.
AC A0A0X3W234;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=ADL30_28215 {ECO:0000313|EMBL:KUL51050.1};
OS Streptomyces sp. NRRL S-1521.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609100 {ECO:0000313|EMBL:KUL51050.1, ECO:0000313|Proteomes:UP000053420};
RN [1] {ECO:0000313|EMBL:KUL51050.1, ECO:0000313|Proteomes:UP000053420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-1521 {ECO:0000313|EMBL:KUL51050.1,
RC ECO:0000313|Proteomes:UP000053420};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL51050.1}.
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DR EMBL; LLZK01000235; KUL51050.1; -; Genomic_DNA.
DR RefSeq; WP_062780317.1; NZ_LLZK01000235.1.
DR AlphaFoldDB; A0A0X3W234; -.
DR Proteomes; UP000053420; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:KUL51050.1};
KW Oxidoreductase {ECO:0000313|EMBL:KUL51050.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053420}.
SQ SEQUENCE 483 AA; 53481 MW; 9436DADEADF8628A CRC64;
MTGTPDQPGP EPLTTPEAPR DLVGIGIGPF NLSLAALAQP LTGLDTAFYD QRPAFHWHPG
LLIEGATLQV PFLADLVTLA APANPWTFLN YLKTRERLYP FYFAERFHIQ RAEYDAYCRW
VSENLPALHF RHHVDAVRWN PEHALFEVDH TRLDTQGEAE ALCRTHAKNI ALGIGTAPHI
PEPLKPLTQA PGVPVIHSAD YLDHRDTLLK AEHITVIGSG QSGAEIFLDL LRARPTGHER
LHWLARTEAF APMEYSKLGL EHFTPDYTRY FHALPEAVRD GLTPRQWQLH KGIDADTIAA
IHDQLYQRTL HGGWPDAVLT PGVAVRTAGR VGATRVELHL EHLQQGTRSR LTTDAVILAT
GYHERPLGQL LAGLDPHIRK DTADRPRVDE QYRLDLDPAI TRTGSNIYVQ NAERHSHGVG
APDLGLAAWR SATILNTLTG AHPYPLPART AFTSFGLQSP HTPGATTTGH IGGQRGKLVR
LKS
//
