ID A0A0X3W2B1_9ACTN Unreviewed; 300 AA.
AC A0A0X3W2B1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Dihydrodipicolinate synthase {ECO:0000313|EMBL:KUL50867.1};
GN ORFNames=ADL30_28860 {ECO:0000313|EMBL:KUL50867.1};
OS Streptomyces sp. NRRL S-1521.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609100 {ECO:0000313|EMBL:KUL50867.1, ECO:0000313|Proteomes:UP000053420};
RN [1] {ECO:0000313|EMBL:KUL50867.1, ECO:0000313|Proteomes:UP000053420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-1521 {ECO:0000313|EMBL:KUL50867.1,
RC ECO:0000313|Proteomes:UP000053420};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL50867.1}.
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DR EMBL; LLZK01000237; KUL50867.1; -; Genomic_DNA.
DR RefSeq; WP_062780497.1; NZ_LLZK01000237.1.
DR AlphaFoldDB; A0A0X3W2B1; -.
DR Proteomes; UP000053420; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF19; 5-DEHYDRO-4-DEOXYGLUCARATE DEHYDRATASE 2-RELATED; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000053420}.
FT ACT_SITE 141
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 166
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 53
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 300 AA; 32062 MW; EA05F9CA00A3A68A CRC64;
MSFETQRAAL ADVVAIPVTP FTEDGRIDRA AHRVILRRLL DGGVRTLTPN GNTGEFYALS
PAERREVVEL THAEAADRAV LLAGVGHDVP TAVAAARHAK EHGASMVMIH QPVHPYVSDA
GWVAYHRAVA EAVPDLGVVP YLRDAGLPGA RLAELVDACP NVIGVKYAVP DAARFAGFAR
DAGLDRFVWV AGLAEPYAPS YFSAGATGFT SGLVNVSPAL SLRMIEALRD GDHPLAMKVW
EQIRRFEELR AADGSAHNVT VVKEALATLG LCRRDVRAPS SLLPDAERAE VAAIVQGWSL
//
