ID A0A0X3XPU3_9ACTN Unreviewed; 395 AA.
AC A0A0X3XPU3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Beta-ketoadipyl CoA thiolase {ECO:0000313|EMBL:KUL74144.1};
GN ORFNames=ADL34_18520 {ECO:0000313|EMBL:KUL74144.1};
OS Streptomyces sp. NRRL WC-3605.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609103 {ECO:0000313|EMBL:KUL74144.1, ECO:0000313|Proteomes:UP000052945};
RN [1] {ECO:0000313|EMBL:KUL74144.1, ECO:0000313|Proteomes:UP000052945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL WC-3605 {ECO:0000313|EMBL:KUL74144.1,
RC ECO:0000313|Proteomes:UP000052945};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL74144.1}.
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DR EMBL; LLZN01000058; KUL74144.1; -; Genomic_DNA.
DR RefSeq; WP_062668859.1; NZ_LLZN01000058.1.
DR AlphaFoldDB; A0A0X3XPU3; -.
DR OrthoDB; 1402717at2; -.
DR Proteomes; UP000052945; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000052945};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 7..265
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..394
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 351
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 381
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 395 AA; 41406 MW; 402FA99754AC84E2 CRC64;
MRPVHFAAAR RTPIGKLRGA LSSVRPDDLA AAVIRGIVAD VPALDPARVD DVYWGAANQA
GEDNRNVARM AALLAGLPDS VPGATVNRLC ASGLEAVTTA ARTIAAGEAD IVLAGGSESM
SRAPFVLPRP DEALPHRIET VDTRLGWRLV NPAMKDLHGL LSMGETAEEV ARRHGVSRER
QDEFALRSHQ RAAEARKNGH FDDEILPVER PDGVLVDSDE CVREDTSLEK LSRLKPVFRA
GGTVTAGNAS PMNDGAAGLL LVSEEALNDL GLESLGRYVA GGSAGVHPDV MGIGPVPATR
KVLDRAGWTV ADLQEAEFNE AFAAQALASV DALGIDPDLV NASGGAIALG HPLGCSGARI
LTTLLHRMRR TGAERGLATM CVGVGQGSAV LVERH
//
