ID A0A0X3XYZ2_9ACTN Unreviewed; 389 AA.
AC A0A0X3XYZ2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KUL80073.1};
GN ORFNames=ADL34_04045 {ECO:0000313|EMBL:KUL80073.1};
OS Streptomyces sp. NRRL WC-3605.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609103 {ECO:0000313|EMBL:KUL80073.1, ECO:0000313|Proteomes:UP000052945};
RN [1] {ECO:0000313|EMBL:KUL80073.1, ECO:0000313|Proteomes:UP000052945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL WC-3605 {ECO:0000313|EMBL:KUL80073.1,
RC ECO:0000313|Proteomes:UP000052945};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL80073.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LLZN01000002; KUL80073.1; -; Genomic_DNA.
DR RefSeq; WP_062668136.1; NZ_LLZN01000002.1.
DR AlphaFoldDB; A0A0X3XYZ2; -.
DR OrthoDB; 3761315at2; -.
DR Proteomes; UP000052945; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000052945};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KUL80073.1}.
FT DOMAIN 5..258
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 267..387
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 345
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 375
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 389 AA; 40842 MW; E60F3209494FA6B6 CRC64;
MRDAVIVEAV RTPMGKGKPN GSLAHIHPVE LLAHTLRSLV ERSGVDPALI DDVIGGTVDQ
VGEQAMNTTR YAALSAGFPE TVPATTIDRQ CGSSQQAVHF AAQGVLSGAY DLVVACGVES
MSRVPMWSNV PPGKDPFGPG IAARYPDGLV PQGISAELIA AKWSLTREEM DAFAVSSHHR
AAAAWQNGLF DAEVAPLDGV SRDECVRPGS TPEILAGLKP AYHDPVFAER FPQIEWNVTA
GNASPVNDGA SAVLITSSET AARLGLRPLA RLHSFAVTGS DPVLMLTGVI PATEKVLRRA
NLSIDDIDLF EVNEAFASVV LAWRQATGAD LAKVNVHGGA IALGHPLGAS GTRLTTTLVH
AMRERGARYA LQTMCEAGGL ANAMVLEAV
//
