ID A0A0X8FCF8_9LACT Unreviewed; 283 AA.
AC A0A0X8FCF8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=2,5-diketo-D-gluconic acid reductase {ECO:0000313|EMBL:AMB94790.1};
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:PKZ23209.1};
GN ORFNames=AWM72_08485 {ECO:0000313|EMBL:AMB94790.1}, CYJ28_01270
GN {ECO:0000313|EMBL:PKZ23209.1};
OS Aerococcus sanguinicola.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Aerococcus.
OX NCBI_TaxID=119206 {ECO:0000313|EMBL:AMB94790.1, ECO:0000313|Proteomes:UP000069912};
RN [1] {ECO:0000313|EMBL:AMB94790.1, ECO:0000313|Proteomes:UP000069912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG43001 {ECO:0000313|EMBL:AMB94790.1,
RC ECO:0000313|Proteomes:UP000069912};
RX PubMed=27103727;
RA Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA Christensen J.J.;
RT "Complete Genome Sequences of Aerococcus christensenii CCUG 28831T,
RT Aerococcus sanguinicola CCUG 43001T, Aerococcus urinae CCUG 36881T,
RT Aerococcus urinaeequi CCUG 28094T, Aerococcus urinaehominis CCUG 42038 BT,
RT and Aerococcus viridans CCUG 4311T.";
RL Genome Announc. 4:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000069912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG43001 {ECO:0000313|Proteomes:UP000069912};
RA Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA Christensen J.J.;
RT "Six Aerococcus type strain genome sequencing and assembly using PacBio and
RT Illumina Hiseq.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PKZ23209.1, ECO:0000313|Proteomes:UP000234239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMB0139 {ECO:0000313|EMBL:PKZ23209.1,
RC ECO:0000313|Proteomes:UP000234239};
RA Thomas-White K., Wolfe A.J.;
RT "Phylogenetic diversity of female urinary microbiome.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP014160; AMB94790.1; -; Genomic_DNA.
DR EMBL; PKGY01000001; PKZ23209.1; -; Genomic_DNA.
DR RefSeq; WP_067976222.1; NZ_PKGY01000001.1.
DR AlphaFoldDB; A0A0X8FCF8; -.
DR GeneID; 69592402; -.
DR KEGG; asan:AWM72_08485; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000069912; Chromosome.
DR Proteomes; UP000234239; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19132; AKR_AKR5D1_E1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000069912}.
FT DOMAIN 18..265
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 50
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 108
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 75
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 283 AA; 32310 MW; BA2E4A802AC14A50 CRC64;
MTIPYYTLRN GDQVPQVGLG TYKLKGRAGV DSIKAALDIG YRYLDTAYNY ENEGTVGQAI
RESGLARDQI QVASKLPGRY HAYDLALTAI EESLYRAQLD YYDYYLIHWP NPKQGHYVEA
WQALIEAKKR GYVKAIGVSN FLPEHIDRLI EETQEVPVIN QVETHPYFQQ AKQIAYDRDH
GILTQAWSPL GRGSEKMSES ILEQELIKKI AEKHGKTPGQ VVLRWHLQIG TMPIPKSSHA
DRLEENFKVF DFELDDDDMA QIARLDHPNG RTGAQNPAVY EEF
//
