ID A0A0X8JW55_9FUSO Unreviewed; 377 AA.
AC A0A0X8JW55;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:AMD95962.1};
GN ORFNames=AXF11_01025 {ECO:0000313|EMBL:AMD95962.1};
OS Leptotrichia sp. oral taxon 847.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC Leptotrichia.
OX NCBI_TaxID=1785996 {ECO:0000313|EMBL:AMD95962.1, ECO:0000313|Proteomes:UP000065271};
RN [1] {ECO:0000313|Proteomes:UP000065271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0260 {ECO:0000313|Proteomes:UP000065271};
RA Holder M.E., Ajami N.J., Petrosino J.F.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CP014231; AMD95962.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0X8JW55; -.
DR STRING; 1785996.AXF11_01025; -.
DR KEGG; lot:AXF11_01025; -.
DR OrthoDB; 634606at2; -.
DR Proteomes; UP000065271; Chromosome.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF91; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2}.
FT MOD_RES 194
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 377 AA; 41717 MW; 1E7237D944C1B232 CRC64;
MKFETKTIHG IKKEKKKELW GTTVNFASTF PVAQFGVTQE FEYSRVSAPT RNQLESLLAN
LEGGKYGYAF SSGMATTASV FTMFEAGDHI ILGQDIYGGT YRILHDVYSK FGVESTFVDT
TDLENIRKAI KPNTRAILIE TPSNPLLDVT DIRGVVKLAK EHNLITIADN TFMTPYLQRP
LELGVDIVIH SATKFLSGHH DLLAGVAVTN DEQLAEKIQF AQTAAGALIS PFDSWLLMRS
LKTLKLRVEA AQKNTEKLIE FFQKHDAVDK IYYPTLDTNK GKKIHESQAT GGGAVFSFTL
KGDSKVKTFF ESLNVAIFAA SLGGAETLVT HPSTITHAEM PEEEKEARGF THSLIRIAVG
FENIDDLIAD FKQALEK
//
