ID A0A100I3F1_ASPNG Unreviewed; 459 AA.
AC A0A100I3F1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=RNA methylase family protein {ECO:0000313|EMBL:GAQ34006.1};
GN ORFNames=ABL_00468 {ECO:0000313|EMBL:GAQ34006.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ34006.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ34006.1}.
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DR EMBL; BCMY01000001; GAQ34006.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100I3F1; -.
DR PaxDb; 5061-CADANGAP00000715; -.
DR VEuPathDB; FungiDB:An01g07400; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1101682; -.
DR VEuPathDB; FungiDB:ATCC64974_17390; -.
DR VEuPathDB; FungiDB:M747DRAFT_287438; -.
DR OMA; QAFNKWS; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:GAQ34006.1}; RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 186..305
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 459 AA; 52417 MW; 92202CAE39F0266A CRC64;
MEYLIRFAQA HESFRQAEIQ ALADLAGVKL EFIHYDKNSP FCTIRLRDEA AARAVITRSI
IAKDIFELWG QGTNFDEVYA DVRRRTEDRW AQYRDSSFRF TIDSFAGKRS SEKKREIIQS
FSFLGFKGPI RMKNPDQDFW VFEDYGLDLN SPGTPRPEGQ EPKIIHFGRW IANSSRDVVN
KYDLKKRRYI STTSMDAELT LITANMAHAA PGKLFYDPFV GTGSFLVAMS HFGAETFGSD
IDGRSFRGKE MMERGGTMGV LSNFQQYDMV GKFMDVFTSD LTNTPLRSAQ FLDGIICDPP
YGIREGLRVL GRREGLRNEE VIIDGVPAHY RPGYIAPKKP YGFEAMLNDI LNFAVRSLVT
NGRLAMWMPT ANDEEVELAV PMHPNLEVVN VSVQPFYTWS RRLITYRRLP EGQVSDVSKG
RQKLDAQGMY ADELNEFRRK YFMKNPPDSS KSGRESSAS
//
