ID A0A100I5A4_ASPNG Unreviewed; 621 AA.
AC A0A100I5A4;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=3-hydroxyacyl-CoA dehyrogenase {ECO:0000313|EMBL:GAQ34967.1};
GN ORFNames=ABL_00980 {ECO:0000313|EMBL:GAQ34967.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ34967.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ34967.1}.
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DR EMBL; BCMY01000001; GAQ34967.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100I5A4; -.
DR VEuPathDB; FungiDB:An01g09740; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1132303; -.
DR VEuPathDB; FungiDB:ATCC64974_15550; -.
DR VEuPathDB; FungiDB:M747DRAFT_242423; -.
DR OMA; LPCQLMD; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
FT DOMAIN 16..192
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..291
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 621 AA; 67945 MW; 82D72123D0FFD6C5 CRC64;
MSTTTTIPHP SKTRPIVVIG AGILGRRIAA VFSSAGYTVH ISDPSSSALD SARTYVSTHI
HEFTTHTPHP SSSPGQISTF TSIPEAVATA WLVIEAVPEI LPLKKTLFAD LHAHSPADCI
LASNSSSYKS RLIGGGHLPL SRRVLLLNMH FTMPPSIRTV ELMTCGETDE RVFPMLSEVL
SECGVIPVTA RKESTGFIFN RLWAAIKREI LLILAEGVSE PKEIDLLWEE MFGRKESLPP
CRLMDAVGLD TVADIEENYV RERGLDGRWT VDWVREKYVS VGRVGKKADE GLGGLYPPDL
TEDVNGKKKV VGEAPLLYLL DVGLGANTSD IEKVSTAGRI LKFQPGITGM APVTIISGQS
LPDGIDVSQT TGRIFWTNMG QSTSTHDGSV HSATLDGQDI CTLLPAGAVH TPKQLVVDDT
TQHVYFCDRE GMSVHRVRFD GSGHEVLVRT GALDDATHRG DMTRWCVGIA LDRKNRHVYW
TQKGPSKGGK GRIFRAGLEV PAGQTADGRE DVEMVLEGLP EPIDLEFDEE EGMLYWTDRG
EHPWGCSLNR VKVGGEVAVQ ESREVLARHF NEPIGLKVDR KDKKVYVADL GGSMYCVDLD
DGEKKVVWRD EGCYTGVALV K
//
