ID A0A100I7Y5_ASPNG Unreviewed; 722 AA.
AC A0A100I7Y5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=MIF domain protein {ECO:0000313|EMBL:GAQ36345.1};
GN ORFNames=ABL_01621 {ECO:0000313|EMBL:GAQ36345.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ36345.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-X/MHF2 family.
CC {ECO:0000256|ARBA:ARBA00009359}.
CC -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ36345.1}.
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DR EMBL; BCMY01000002; GAQ36345.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100I7Y5; -.
DR VEuPathDB; FungiDB:An01g10680; -.
DR VEuPathDB; FungiDB:An01g10690; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1083140; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1132368; -.
DR VEuPathDB; FungiDB:ATCC64974_14910; -.
DR VEuPathDB; FungiDB:ATCC64974_14930; -.
DR VEuPathDB; FungiDB:M747DRAFT_297830; -.
DR VEuPathDB; FungiDB:M747DRAFT_333524; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR InterPro; IPR018552; CENP-X.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR001398; Macrophage_inhib_fac.
DR InterPro; IPR014347; Tautomerase/MIF_sf.
DR PANTHER; PTHR28680; CENTROMERE PROTEIN X; 1.
DR PANTHER; PTHR28680:SF1; CENTROMERE PROTEIN X; 1.
DR Pfam; PF09415; CENP-X; 1.
DR Pfam; PF01187; MIF; 1.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR SUPFAM; SSF55331; Tautomerase/MIF; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 425..452
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 79437 MW; 95EE8F982810B601 CRC64;
MTARRHRIDF SLRRRRNDLS NTSSGSISPP VPVLQSPVTF QAFASVNVSE ATLKQKNKLE
RAPVRPSMFL EEKDDDEAPI SALTGGAPLD VKPAHVERKS VEEKPMTRTK SQYFEDAFST
RGPLTSPRTQ ISQDSVVVVE IKVNTKVKEM ESLVSNISSH MARIFQKSET LMMTTIQDDA
CIQFGRVNLP AYLMKVFALP YLIAPITNLR STILIQAALQ EILHVAPNRG VILYIPIPEE
NFATNGVTMM GEIARLERSS PDHGSGLFKT VSRTMSRRLK STSSQSAPIS VATTSSWACG
GTQAPSPGKE SLASDATDSD VKSKSDACNC RGTWGKGIAR VFRSNYPAAY EVYRSYCRQF
SSKPRYDTVT TSDGTRKARL PEGTALIIPP QKRDHENDRR KRHWIICLFT SRGLGRMVSP
ENIVLENTEL AIADMKKQLD RIEDQKGSLL ELWSCRFNSG LFDSKSPDHA SRTRASAQED
QIPATNTPYH QLTTKVTNLD TKTQHTMPPE RKPAQKRRQL PFKPPSRTSS TAAAPASSSS
TTSKPKGKAT TKSTTTTAAS KRGPKPKEAS AKASSSKSAR PRPSSPSPAD SDEDSNNDND
NASSSPARSD ASSPEPEPEP DYILAEIIHK DQPSDDVLTN DPVIPPKLLT RLLHHHFQNE
KTKIAKDANT VVAKYVDVFV REALARAAFE RTEAVGKGAS VGDGFLEVED LEKMAPQLVM
DF
//
