ID A0A101GFS8_9BACT Unreviewed; 820 AA.
AC A0A101GFS8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 13-SEP-2023, entry version 38.
DE SubName: Full=DNA mismatch repair protein MutS {ECO:0000313|EMBL:KUK57456.1};
DE Flags: Fragment;
GN ORFNames=XD80_1394 {ECO:0000313|EMBL:KUK57456.1};
OS Synergistales bacterium 53_16.
OC Bacteria; Synergistota; Synergistia; Synergistales.
OX NCBI_TaxID=1635273 {ECO:0000313|EMBL:KUK57456.1, ECO:0000313|Proteomes:UP000053116};
RN [1] {ECO:0000313|Proteomes:UP000053116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26787827; DOI=10.1128/mbio.01669-15;
RA Hu P., Tom L., Singh A., Thomas B.C., Baker B.J., Piceno Y.M.,
RA Andersen G.L., Banfield J.F.;
RT "Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and
RT Other Microbial Community Members in Biogeochemical Transformations in Oil
RT Reservoirs.";
RL MBio 7:e01669-15(2015).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUK57456.1}.
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DR EMBL; LGGB01000142; KUK57456.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101GFS8; -.
DR PATRIC; fig|1635273.3.peg.1493; -.
DR Proteomes; UP000053116; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}.
FT DOMAIN 637..653
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 750..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 376..403
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KUK57456.1"
SQ SEQUENCE 820 AA; 90480 MW; 5787F9E6E43E1928 CRC64;
ASRILDIALT SRDPNREIPM AGVPWHSAES YIARLVQKGH KVAICEQVTE PDGRNLVDRE
VIRVITPGTF VPSDSPMEGR LAAFTVSGDD ACIALLSSGT GRIEAGSMPR EQAMAELAAF
DPMELLIPRN MPSSEKSALR QAFRASLVEA DPDAFEPTEA SRRLCEAWKV ATLEGFGIEK
GSPVCGCAWV VFDYLSQTQF GAACHVRRIF PLRGGAYLYM DRATQVNLEI AESDSMSLAG
VLDDCRTAMG RRLLRRWLLH PLVDPEEISS RHEAVEVLTE RPEMLRALRG ALSACGDAER
AVARMGMRLA APRDLGVIRD TLSALPLLRD VLSRLPLPEP WGFVADPGDL AQELAAALAD
ELPRALREGN VIRKGYDAKL DELRGLKERA KQFLDEMLEG ERRKTGIKNL KLGFNKVFGY
YLEVSRSNLD QVPPEYVRKQ TLVGAERFIT GELKKFEEKM LSNDEDIRVR EEELYAELCG
KVLDKTALIQ DIASSLASLD VLASYAAVAL ERGYKRPSVD RSYVLDFRDA RHPVVEIMLD
DAPYTPNDIL LDSETRRMAV VTGPNMAGKS TYLRAAALLV VMAQAGSFVP ASFARLGTVD
RIFSRIGARD ELARGKSTFM VEMVETASIL HNVTPRSLVI LDEIGRGTST YDGVSIAWAV
MEYLHSAADG MAKVLFATHY HELSALAEKM PGVFNLSFSV EETDRGVLFL YRLKESPADR
SYGIEVARLA GVPDAVVRRS QELLRRFEAE GGIRGPSGQG EPAKSSSRDS GFGQLRLFRT
GAEDILRELA AADPDGMTPL EALELLYVLK ERAREVLEEK
//
