ID A0A101PCW0_9ACTN Unreviewed; 1584 AA.
AC A0A101PCW0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:KUN09175.1};
GN ORFNames=AQI95_04815 {ECO:0000313|EMBL:KUN09175.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN09175.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN09175.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN09175.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN09175.1}.
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DR EMBL; LMWN01000006; KUN09175.1; -; Genomic_DNA.
DR RefSeq; WP_067117834.1; NZ_KQ948207.1.
DR STRING; 67386.AQI95_04815; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..449
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1430..1505
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1584 AA; 165401 MW; 7596933EB3A65B2B CRC64;
MEDSATAGKL RDYLKRATTE LERSRRRVRE LEEQDREPVA IIGMGCRYPG GVRTPEDLWR
IVDEGIDVVT EFPTDRGWDV EAIYDPEPGA PGKSYVRHGG FLHDAAECDP AFFGISPKDA
PGTDPQQRML LEVTWEAFER AGIDPTTVKG SSTGVFVGLM HHDYIGGTIS GSIVSGRIAY
TLGLEGPAVT MDTACSSSLV ALHSAIQSLR KGECSLALAG GAAVMASPEM FIEFSERRAL
SPDGRCHSFS DDAAGAAWAE GAGMLLVERL SDALRNGHEV LAVVRGSAVN QDGASNGLTA
PSGPAQIRVI EQALADARLA PHHIDAVEAH GTGTTLGDPI EAQSVIAAYG QDRPENQPIL
LGSIKSNMGH PQAAAGVGAV IKMVMAMRHG TLPRTLHVEK PSTAVDWSAG DIELLTEPRA
WHTPDGRPRR AGVSSFGISG TNAHTILEEA PAVEAEQPAP ERAALPVVPW VLSGKGSDAV
QRQAERLLAA AADLDPYDVG FSLATTRTRF THRAAVTGRD RDELLAALRA VADGSQAAVV
TPEPGRLGVL FSGQGSQRPG MGRTLHAAFP VFAAAFDEIC AAFDAHLERP LREVMFEEAA
DPAASPLNQT VYTQAALFTF ETALYRLLEH WGVRPDLLAG HSIGEVVAAH VAGVLELKDA
VALVAARGRL MQELPTGGAM VSLLASEAEV TPLLTDGVDI AAVNGPRAVV ISGDEEAVLA
VAAQVEKTTR LKVSHAFHSH RMDPMLDAFR EVLEGLTFHE PALPVVSNVT GRMADALTSP
EYWVRHVREA VRFHDGVTTL AAEGATRFLE VGPDSVLTNM AQDVVPDVIG AQRRDRDEDA
TLVDAVSRLQ LTGSGPDWTA VFAGGRKVDL PTYPFRRDRH WEDAPILQAE RSAAARAGGD
AADPFWELVR DQDVPAVAAT LGVADETSVA AVVPALAAWH EQRQANAAAD GWRYRVAWEP
LAPAATPALG GHWLAVVPAD DDPWTLAVLT GLADRGVTID TLTVPLAADR AELAGLVAGR
GDVDGVLSML APATDVTSTA ALVQALGDAE ITAPLWCATR DAVAHGTAAE VTGFAQAQVW
GLGRVAALEH PDRWGGLIDL PAEIGPQTVA RLAALLGDAG GEDQVVIRES GAYGRRLEHA
PARAGAPWKP SGTVLVTGAT GAVGTAVARW LAAEGADHLL LTSRRGTDAP GADDLVAELT
GTGTEVTLAA CDVADREALA ALLDSVPEEH PLTAVLHLAG VLDDGVLDAL TPDRFAGVLA
AKADSARHLH ELTAERDLSA FVLFSSLTAT VGGAGQANYA AANAYLDALA EHRQAAGLAG
TSVAWGPWGG DGMAAHGTVR SAARAMGMSL LAPERALTAL GRALDGGDTT VTVADVDWSV
FAPAFTSSRP SALLSALPEA RRGTGGGAEA GAADGFAEKL AGLTGGERDR ALQELVCGQA
AAVLGYGSAD AIEATTAFRD LGFDSLTSVD LRNRISSAAG VPLPATLIFD YATPAALAKH
LGTELAGADT SVDSVVAELD RVAARLGDLT AEDIEQGRIT TRLQSLLADL NKTLGQDAAA
VAGRLEDASA DDVFAFIDNE LGSA
//
