ID A0A101QYY7_9ACTN Unreviewed; 1887 AA.
AC A0A101QYY7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KUN38633.1};
GN ORFNames=AQJ30_13915 {ECO:0000313|EMBL:KUN38633.1};
OS Streptomyces longwoodensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68231 {ECO:0000313|EMBL:KUN38633.1, ECO:0000313|Proteomes:UP000053271};
RN [1] {ECO:0000313|EMBL:KUN38633.1, ECO:0000313|Proteomes:UP000053271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41677 {ECO:0000313|EMBL:KUN38633.1,
RC ECO:0000313|Proteomes:UP000053271};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces longwoodensis DSM 41677, type strain
RT for the species Streptomyces longwoodensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN38633.1}.
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DR EMBL; LMWS01000015; KUN38633.1; -; Genomic_DNA.
DR RefSeq; WP_067233225.1; NZ_KQ948552.1.
DR STRING; 68231.AQJ30_13915; -.
DR Proteomes; UP000053271; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053271};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..461
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1729..1804
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 462..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1887 AA; 195904 MW; 0F8D868334316062 CRC64;
MAENEEKLLA YLKRVTGDLR QTQRRLREAE AAHSEPVAIV GMACRYPGGV DSPEGLWDLV
ARGGDAVTGF PTDRGWDVEG LYDPDPARSG GNYVRGGGFL DGVTDFDAGF FGISPREALA
MDPQQRLLLE GAWELFERSG IDPASLKGSP TGTFIGFSSM DYGWELPRIP ESVEGYFATG
NFASVMSGRI AYTFGLEGPA VTVDAACSSS LVALHLAAQA LRSGECSLAV AGGVTVMSTA
VGYAEFSRQR ALSPDGRCRA FSASADGFGP AEGLGLLLVE RLGDARRNGH RVLAVVRGSA
VNQDGASNGL TAPNGPSQER VIRAALRNAR VSPDEVDAVE AHGTGTPLGD PIEAHALLAT
YGERRPQERP LWLGSVKSNI GHTSAAAGVA GVIKMVQALR HGVLPRTLHA DEPTPHVDWS
PGTVRLLTEP RPWPDTGDRP RRAGVSAFGI SGTNTHVILE QAPATPPDDT ESAPAPGTPS
GLTATAVPLP LSARSAPALR AQAERLTAYL TAHAEAPLDG IGRTLATARA ALDHRAVLLA
TDRDQTLTAL AAVSAGNPDA HVVQGVALTD GTEQELAGRV VFVFPGQGSQ WVGMGAGLWE
SSPVFRERLA ECDAALSALV DWSVTDVVRG LPSAASLDDV VVVQASLWAV MVSLAAVWRS
VGVEPGAVIG HSQGEIAAAV VAGGLSVEDG ARVVVLRAQA IAESLSGNGG MVSVAVSADR
VRELIARWGE RISIASINGP TSTVVSGEPG ALDELTAACE AEGIRARRIA VDYASHSAQV
ESIRDQVVEA LKNIEPGPAQ VPFYSTVTGA VIDTSGLDAT YWVTNLRQEV RFDATVRELL
TDGFGYFVEC SPHPVLTVGM QETFEDHADA QAAVALGTLR RDEGGPERFL TSLAEGYVRG
LTVDWIALFA GTTDAEPLLD LPTYAFQRRR YWLDGGAAAV TDPSGLGLAD AGHPLLGATV
HVADDERKLL TGLLSRRAQP WLADHVVHGT ALVGGATVAE LALAAAAQAG AELVEALVVE
APLPLPEKDG VQIQLSLGAP DTDERRELAL YARPGDALPD TPWTRHARGT VATSTSPTEP
PAEEPFGTWP PEGAVPVGTG GAYERLEPVG YGYGPAFQGL RAVWRRGEDL FAEVALPDEQ
ARDAGAFGLH PALLDAALHP ALLDHLDGAD DTGLRLPAEW HGLALHAVGA TVLRVRIRPT
GPGAVSLLLA DAAGNPVASV DEVRLSEHAP EDVAGAARSL RDALFRLEWT PFDRPLPAVA
PAGWTVVGPD ELGIGAGAEQ DAEPSLALAS FVSSAEGAPG AALAPRVHEA ATAALGLVQK
WLADERSEAV PLVLVTGGAV AAAPGDRVTD VVNAPLWGLV RSVQAEYPAG RFLLVDVDGH
EASRTALAAA AAAALEAGEP QLAVRNGTAL VPRLVRAEAP TQDTATPFSA SGTFPASGTF
PASGAFPTSG TVLVTGGTGT SGARVARHLV AAHGVRHLLL IGRRGPDTPG ATELLDELHA
LGADTVDLVA CDAADRDALA DVLASVPASR PLTAVVHAAG VLDDALTTSL TAPQLERVLR
PKADAALHLH DLTRDRELSA FVLFSSAAGT LGNAGQANLA AASTVLDALA EHRRALGLPA
VSLAWGPWTT EGNEEEDGGA AGGGVLPFSP SEGLALLDAA LADGAALAVP VRLDLPALGA
AAAAGTLPAA LRRLVRVPAR RAAASGPGTA ADTGLARELA AAPEAERRRI LLDLVRTEVA
AVLRHATVDD VEADRAFKEL GFDSLTAVEL RNRLGAATGL RLPPTLVFTY PNPTALVRFL
LDEIAPGAGE GATTPVLAEL DRLDADLSGL TPDDATRDRI TRRLEALLWK WSGEPDGEEA
VLGRETLEDA SDDEMFALID QELGEAG
//
