ID A0A101WFL6_9FIRM Unreviewed; 641 AA.
AC A0A101WFL6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Aconitate hydratase {ECO:0000313|EMBL:KUO72134.1};
GN ORFNames=APF77_00935 {ECO:0000313|EMBL:KUO72134.1};
OS Clostridia bacterium BRH_c25.
OC Bacteria; Bacillota; Clostridia.
OX NCBI_TaxID=1734399 {ECO:0000313|EMBL:KUO72134.1, ECO:0000313|Proteomes:UP000057710};
RN [1] {ECO:0000313|EMBL:KUO72134.1, ECO:0000313|Proteomes:UP000057710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRH_c25 {ECO:0000313|EMBL:KUO72134.1};
RA Bagnoud A., Chourey K., Hettich R.L., De Bruijn I., Andersson A.F.,
RA Leupin O.X., Schwyn B., Bernier-Latmani R.;
RT "Microbial metabolic network in the subsurface.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO72134.1}.
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DR EMBL; LOES01000157; KUO72134.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101WFL6; -.
DR STRING; 1734399.APF77_00935; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000057710; Unassembled WGS sequence.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR006250; Aconitase_put.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR NCBIfam; TIGR01342; acon_putative; 1.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF3; ACONITATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF00330; Aconitase; 2.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 7..284
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 286..407
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 524..575
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 641 AA; 70191 MW; 257D951A0C73FAA7 CRC64;
MGMTLTEKLI TSHLVRGTMK RGERIGIKID QTLTHDVNGV MAYLEFEALG IKKVKGDLAV
SYIDHNMLQA DFRNPDDHRF LIDMAKKLGS ICSRPGNGIC HQLHVERFAI PGKTLLGSDS
HTTASGGVGM LAMGAGGLDV AMAMAGEPFY FNMPRIIKVV LSGRLQPFVS VKNVNLELLR
RLTVKGGLNA VLEYDGPAIK DLNVTERATL CNMGTETGAT TSVFPSDEMT KFWLQAQSRG
QAWTPLHADF DAVYDDIIEI DLSGLEPLIA LPHQPDNVVP VREAAGIGID QIMFGGCTNS
SLQDVLSIAH MMDGSRVHNN VDAGLYCGSQ QVMLECVQRG TLEKLIRSGV RILEMFCGAC
NGMGFAPPTN GISLRTGPRN FIGRCGHPTG HVYLVSPETA AASAVHGRIT DPRDLRRPVR
TYAMPDKFII DDSRFIYPEA AITEDRPIRR GPNICPLPEI EPIYDELRGE VLLNVGDDIT
TDHIVPAGAN FLPMRNNTPE IAKHVFKVLD ETFAERARAA GNGFVIAGFN YGQGSSREQA
ALAPRYLGVR AIIAKSFARI HMANLVNFGI LPLILNDFES KLQFEQGDFL RIDTVVLREG
EDYIVHNLSK GIEAAVKSPL SQDELDIIKV GGRLNWIKLH S
//
