ID A0A102DCY2_9SPHN Unreviewed; 691 AA.
AC A0A102DCY2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:KUR79221.1};
GN ORFNames=AQZ50_05070 {ECO:0000313|EMBL:KUR79221.1};
OS Novosphingobium sp. Fuku2-ISO-50.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1739114 {ECO:0000313|EMBL:KUR79221.1, ECO:0000313|Proteomes:UP000056630};
RN [1] {ECO:0000313|EMBL:KUR79221.1, ECO:0000313|Proteomes:UP000056630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fuku2-ISO-50 {ECO:0000313|EMBL:KUR79221.1,
RC ECO:0000313|Proteomes:UP000056630};
RA Ruckert C., Winkler A., Glaeser J., Grossart H.-P., Kalinowski J.,
RA Glaeser S.;
RT "Draft genome sequence of Novosphingobium sp. Fuku2-ISO-50 (=DSM 27930), a
RT Novosphingobium acidiphilum related species isolated from a surface water
RT sample of the southwest basin of Lake Grosse Fuchskuhle.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUR79221.1}.
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DR EMBL; LLZR01000007; KUR79221.1; -; Genomic_DNA.
DR RefSeq; WP_067743405.1; NZ_KQ954286.1.
DR AlphaFoldDB; A0A102DCY2; -.
DR STRING; 1739114.AQZ50_05070; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000056630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR PROSITE; PS51318; TAT; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000056630};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..235
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 268..588
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 630..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..691
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 74724 MW; C384C6CB9A11F211 CRC64;
MKKQKLPMTA ARLTQTFERR TFLLGAVQGG VGLLLAARLG YLAVAQNAKY RAASESNRVN
LSLIPPRRGW VLDRNGTALA SNRADFRVDL IPDRLDNPDA TLSTLQSLLS LTPDHLADIK
DKIDKSRGFQ PVEVASKLDW DKFAAVSVRL PELPGVIPQR GFSRFYPSGA AVGHLVGYVG
PASADDYVRE HNPLLITPGF KIGKDSLEKV FEMRLRGVPG ARRVEATASG RVVRELGTRE
DVPGQPIQLT IHAGLQEYAA RRIGLESGSV VVMDCLTGDL LAMVSMPCYD PNSFSDGIGR
IEWKMLSEDD HVPLRNKVLR GLYPPGSTVK PMVALAFLEA GLDPHATVNC AGGLRVGNRV
FHCWNHHGHG TTDMMKGIYQ SCDVYFYHFA QQIGMDAIAK MMRRMGLGSS FPLPYPGQSY
GTVPDPAWKL RKYHKEWAVY DTVNATIGQG YMLVNPLQQA TYVSRLASGL KHSPRLILDR
HAPPSPSMGF RQDHLDLIHA AMNEVVNGRG TAGKARIPIP GVQMAGKTGT AQVVGLNLGN
GKGGEWKRRD HGHFICFAPF DKPRYACAVA IEHGGGSGSA YPIARDVMTY LFDQDKAMAV
LTDYESQWGG TTQQRMAAKY AAYAAKYGAT APAPPSDDAA NDQTDANNRD DEPATPVTDA
ASPAPEPEAS PTPAPSSAPP TPAPSSGAAP Q
//
