ID   A0A106BKN7_THIDE        Unreviewed;       962 AA.
AC   A0A106BKN7;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=ABW22_12650 {ECO:0000313|EMBL:KVW94236.1};
OS   Thiobacillus denitrificans.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Thiobacillaceae; Thiobacillus.
OX   NCBI_TaxID=36861 {ECO:0000313|EMBL:KVW94236.1, ECO:0000313|Proteomes:UP000064243};
RN   [1] {ECO:0000313|EMBL:KVW94236.1, ECO:0000313|Proteomes:UP000064243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RG {ECO:0000313|EMBL:KVW94236.1,
RC   ECO:0000313|Proteomes:UP000064243};
RX   PubMed=26712544;
RA   Harrold Z.R., Skidmore M.L., Hamilton T.L., Desch L., Amada K.,
RA   van Gelder W., Glover K., Roden E.E., Boyd E.S.;
RT   "Aerobic and Anaerobic Thiosulfate Oxidation by a Cold-Adapted, Subglacial
RT   Chemoautotroph.";
RL   Appl. Environ. Microbiol. 82:1486-1495(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KVW94236.1}.
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DR   EMBL; LDUG01000036; KVW94236.1; -; Genomic_DNA.
DR   RefSeq; WP_059757231.1; NZ_LDUG01000036.1.
DR   AlphaFoldDB; A0A106BKN7; -.
DR   PATRIC; fig|36861.3.peg.2314; -.
DR   Proteomes; UP000064243; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046819; MmeI_hel.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR046817; MmeI_N.
DR   InterPro; IPR046820; MmeI_TRD.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20465; MmeI_hel; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   Pfam; PF20464; MmeI_N; 1.
DR   Pfam; PF20466; MmeI_TRD; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:KVW94236.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000064243};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KVW94236.1}.
FT   DOMAIN          5..177
FT                   /note="MmeI-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20464"
FT   DOMAIN          186..255
FT                   /note="MmeI-like helicase spacer"
FT                   /evidence="ECO:0000259|Pfam:PF20465"
FT   DOMAIN          335..519
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
FT   DOMAIN          651..847
FT                   /note="MmeI-like target recognition"
FT                   /evidence="ECO:0000259|Pfam:PF20466"
SQ   SEQUENCE   962 AA;  107793 MW;  1649109D17DDB889 CRC64;
     MPQRSDQLRH FVDWCAAHIK GDEKGEAQIF LDQFFRAFGH AGAKEAGATF EDRIKKEGKG
     TSFADLVWKP LVLVEMKKRG EDLTKHYRQA FDYWVRLVPG RPRWVLLCNF DEFWVYDFET
     QMDSPVDQVR LAELPERYGP LAFMFPEGDE PVFGNHQEQV TRAAADQLVA LFRALIRRGI
     ERGLAQRFTL QSLMALFAED IGLLEKYFFA RLLEDCATPT QAYDLIGQLF VEMNTPGVTA
     GGRFKGVSYF NGGLFAQPAR IELMAGEIQL LRDAARFDWS KVRPEIFGAI FEHSMDAEAR
     HAYGAHYTSP VDIMKIIGPT IVEPWRAQIE KAKSLGALKR LLVRIENFHV LDPACGSGNF
     LYIAYRELKR LEARIYERMG EYASVKSEQR PFGFVTARNF HGLDINPFAV ELAKVTMMLA
     HKLAIDELHI EEAALPLDNL DANFMVGDAL LREDGSRSPW PAADVIVGNP PFLGAKLLKP
     NFGTDYVKRL RKAYPEVPGM ADFCVYWFRR AETHLPTCTA QDPLAGRGGL VGTQNIRNNA
     SRVGGLDAIC ASGTVIEAVD NQPWSGEANV HVSIANWVKT QDDVLLPKQR RLWFKIEPAK
     GGARRPRGSG QASKDYELDM REVAHINASL SDKVDVGGAA LLSCNEGVCY TGQYPRHKGF
     MLTAKQAQSM LKDSINNDVV KLFMVGEEML TTGRTDRYVI DFQTRDILDA QRYLAPFEHL
     RQQVLPHVQT LAATEKLKSG KDTGQDQNWL KTWWQHFRCR PELIGKLSKL PRYLACSRVT
     KRPIFVFVDA AIRPGDALQV FALADDYSFG ILQSVAHAQW FIANCSKLTE RLRYTTETVF
     DTFPWPQAAA IEQVDAVAEA GRRLRALRDQ SLQSMNGGLR ALYRTLDLPG KNPLRDAHDA
     LDAAVLKAYG FNPKCDLLEQ LLHLNQQVAA EIAAGKAGVG PGIPAGYLNP SGLVSSDAYQ
     PS
//