ID A0A109IPC2_9ACTN Unreviewed; 661 AA.
AC A0A109IPC2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=GA0070623_5405 {ECO:0000313|EMBL:SCG81032.1};
OS Micromonospora rifamycinica.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=291594 {ECO:0000313|EMBL:SCG81032.1, ECO:0000313|Proteomes:UP000198226};
RN [1] {ECO:0000313|EMBL:SCG81032.1, ECO:0000313|Proteomes:UP000198226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44983 {ECO:0000313|EMBL:SCG81032.1,
RC ECO:0000313|Proteomes:UP000198226};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; LT607752; SCG81032.1; -; Genomic_DNA.
DR RefSeq; WP_067301903.1; NZ_LT607752.1.
DR AlphaFoldDB; A0A109IPC2; -.
DR OrthoDB; 308915at2; -.
DR Proteomes; UP000198226; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR CDD; cd06577; PASTA_pknB; 4.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.10.20; -; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR NCBIfam; NF033483; PknB_PASTA_kin; 1.
DR PANTHER; PTHR24348:SF22; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR Pfam; PF03793; PASTA; 4.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00740; PASTA; 4.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51178; PASTA; 4.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SCG81032.1};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:SCG81032.1};
KW Transferase {ECO:0000313|EMBL:SCG81032.1}.
SQ SEQUENCE 661 AA; 70224 MW; 24A25E3EE3BF5DA4 CRC64;
MDIQVADTLL GSLLDGRYRI RGRVARGGMA TVYTATDERL ERTVAVKIIH PSQATEARSR
LAGFPGRFTD EAKAIARLTH PNVVAVYDQG THQGLPYLVM EYVRGRTLRE VLAERRRLNP
DEALAIMEQM LAAIAAAHRA GLVHRDVKPE NVLVAEAPTG GVANLVDSVV KVADFGLARA
VEASAEEGDG NQLMATVAYV APELVTDGQA DPRTDVYSAG IVLFEMLTGR VPYDGDRPVE
VAWQHVDRDV PAPSILVPGL PRVLDELVGR ATRRDPGARP ADAGALLAEV QVARDELGNP
NAHTAVLGRV GEELPAVAQP TMVVAAVSPV NRPTWARLPE PVAPQRPHRR RAVEDAALGS
RFAQLRTRVM GTPRGRLSVA AAVVVIGLLA AMGGWWVGVG RYTVAPQLVN LSRADAQAQA
DRAGFRLSFA EPRYDEKIPR DGVVAQDPGS AAKILKGGTI TLTLSLGPER FPVPDVVGKE
FDLAEADLTG AKLVVAKGSP RYDDNLPAGV VVDTNPKVGT EVKPGTKVTV ILSRGRAPVT
VPDLVGKSLG DARTALSQLG LVAVETYKES DKPRDEVLGQ SPADGAGVEK GTKVKLDVSK
GPPQVTVPRV VDLPCQQAKQ QLEGAGFTVN VQFNPNGIVR FQNPGENSQV PPGTPVTLGC
L
//
