ID A0A117DWL6_ASPNG Unreviewed; 2332 AA.
AC A0A117DWL6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Sensor histidine kinase/response regulator {ECO:0000313|EMBL:GAQ36638.1};
GN ORFNames=ABL_01777 {ECO:0000313|EMBL:GAQ36638.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ36638.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ36638.1}.
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DR EMBL; BCMY01000002; GAQ36638.1; -; Genomic_DNA.
DR PaxDb; 5061-CADANGAP00002304; -.
DR VEuPathDB; FungiDB:An02g08510; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1088820; -.
DR VEuPathDB; FungiDB:ATCC64974_55730; -.
DR VEuPathDB; FungiDB:M747DRAFT_44924; -.
DR OMA; QLPGYTW; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF46; HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:GAQ36638.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 57..383
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1890..2113
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2151..2274
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 57..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2287..2332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2287..2313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2205
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2332 AA; 259287 MW; 01F883453D8F7F66 CRC64;
MEDSHILGDD LPLPPARLFE RLGHLPGYTW DQTIEPFHST YNHWHVFGLR HAAESDVSTP
AATSSGPSSL ARNSPRTESR PPFRHHWRSS LSESSSELSL SRMDHESIWI PVLARVSSHV
VRLEREFHML RSIVQTSDPD CNHTIRPIDL IRLPSDPGDA GPLLVAIFES PGQNMLREMV
AFGPAWFAAG GRTDSNEPTP GEQVSLSTFL DFAIGACDCL ELLHYGLKTV HGEIRGDAFH
FNREAGSVKL TNTGNGARSF DNILSEGWSS LSKELGVKNK LQFIAPEQTG RMPTEPDSRT
DIYALGVLFW TMLVGKPAFT GSDPVEVVQN VLGKKLPPLS AKRMDVPDAV SAVIQKMTQK
AVNERYHTIS SVKRDLAQIS QLLGDGDSEA LKDFQIAQRD VSSFFTLPSR MFGRGEEYDR
IINVVEKVHR RQQAAYARAA AQTSSGVGSN SSVSDGRVDS FEIASGSSDS GSFNLASRAA
SNGGAYNIGR TSTHESLHST DSSPSTPKPG DSSGKPRSPV ESRASWENVD RDGHPSAGTS
TQSHGDSIGS VARAKAAHKV RRPGKCEVIT ISGAAGIGKT DLLNRVQPAI RKLGYIGIAR
LDRARRIPFE PFAKILASLL RQIFSERDVT TEYHNNIRTA LRPMWPTLHR VLELPEQLMS
SGGNERQISP RLSAAQHIFK EVSTKGEPSK RVALPSLDHG QSSVDFFLSN AALKNMRLME
TFLEILRTLS QYRLICACVD DLHYADDETL ELIMNIVKAK IPCVLILTSR KSELESNIIR
PLFDSENPSV TRVVLKPLGE EEIMQIVAAT MHQEPNPMLT PLAAVIQEKS MGNPFFVRMM
LETCYSKNCI WYSWKNSVWE FDLDRIFTEF VAPRYGEGLG LGFIARRLQE IPPAARSIMV
WGALLGSPFA FSLVQKLLTS EFLYSSEDDE AVDLTCPQNA NLIRQTEADM VVGLQYLVQA
NLIIPGKTDD EFRFVNDRFS QAALSLTEGR NVEKMHFIIS QAMMKYYHDG RSRYAMARHV
ALASRIIKSR VVERLEYRKI LWDAAQTAAQ SGARPTALWY FRHCITFLQD NPWDDNNADV
YYRETLRLHI ATAEMSWSQG HNTEALDLLD KVFEHGKSAV CKSRAWIVKA KIYAQMGNHL
RSMDSLLTCL EELGVHLREP TTYDECDDAY RNLRAYLEQA DLEAIVRKPV SKDVDMITIG
EVMAEAMAVT YWDDALTFYR MAIEMMNLHL FKGGFVQISI GCSHLAMISF SRFRDLELAV
RLSDFALTLL ERCPEQWTQS RGSIVHNLYV GHLRVPLSST LPNLEASVET SFSMGDPYIT
LISLSSMAMT RLYLGHDMAQ VEAFCNESPE DIPDWVNDTR GGASLLAVRQ VARALQGKTA
CRSPDTIMSD EHHHTNEYIA FLDNNASNAD RPRDIYWGLA MIPLFAYGHH TKAIQLGMQM
METMPRLWSA RVSYVVYFYL ALSLLTLHNE YPARGYLDGS LHTVLKYKAE VDFARSACDA
NYGMWSLILE ALICEVRNDH TSAIQSFEAA IDHCQIHGWP LEEALALELH GEFLIRRGAK
RAARSVMQDA IAAWAAISAV GKAAQLTEKH EWLLKTATSS RNVDAGCQTV DSLLGINRNT
GQEHMGVAQN MEEDDRKQRW IEQNGVTTGE RSFDISGVGL DIIDLSSILE SSQVMSSELQ
IDKLLTKMIE IVLESCNGSD SAVIATNFDN NFTVAAAGDL EKGQKSFVDG LPFSEIEDKM
AHQISHYVMR TREEVLVHNV LEDERFSNVN EGYQARYPLG RSVIALPIMQ AEHLLGVIHI
EGKPNSFTQR NVVVLHLLCN QIGISLSNAL LFREVRKVSA TNASMVEAQK RALAQAREAE
QKAKVAEAEA KHNVKLKEDA AKAKSIFLAN ISHDLRTPMN GVIGLSELLK GTKLDREQDE
YVESIRVCAD TLLTLINDIL DFSKLEAGKM KISTVPLNIR ETISEVVRAL RYTHRDRGLE
TIEDLDKVPP ELVVLGDPVR LHQIFMNLLS NSYKFTPKGS VTVRAKVSRE GKGRVRLECS
VSDTGIGISE EQKSRLFRPF SQADNSTARS YGGSGLGLSI CKAIIEDVLG GAIWLDSTSG
VGTTVTFHLA FNKVKDAAAK AAKNKAANQA ENKAPVPTAR DLTMVPRDQI RVCIAEDNPI
NQKIAVKFVK GLNLQCEAYS DGRQAVEALR TRSREGNPFH VVLMDVQMPT LDGYNATREI
RKDPDPNVNE VLVIAMTASA IEGDREKCLG AGMNNYLPKP VRSTILSEML DQYLAPVPAY
TRTRLVNRER GSVSTEAGTP RSNSMSPNID GQATALTPEE DKQLQERQPI EN
//
