ID A0A117MKD8_9ACTN Unreviewed; 342 AA.
AC A0A117MKD8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:KUL22192.1};
GN ORFNames=ADL12_42960 {ECO:0000313|EMBL:KUL22192.1};
OS Streptomyces regalis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL22192.1, ECO:0000313|Proteomes:UP000053923};
RN [1] {ECO:0000313|Proteomes:UP000053923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL22192.1}.
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DR EMBL; LLZG01000399; KUL22192.1; -; Genomic_DNA.
DR RefSeq; WP_062713697.1; NZ_LLZG01000399.1.
DR AlphaFoldDB; A0A117MKD8; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000053923; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053923};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..339
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 342 AA; 36026 MW; B773B9AFF9C39D24 CRC64;
MRALVYHGPA QASWDTAPDP SIEEATDAVV RIDAATICGS DLHILRGDLA EVKPGTVLGH
EAVGEVMEVG SEVHHLRPGD QVIVSSVSAC GHCQSCRDGM HGQCHGGGGW ILGSLINGTQ
AEFVRVPFAD FSTHRRPWNL ALDDAILLAE VLPTAYEVGV RNGHVSPGDT VVVVGAGPVG
LATVVVARLY SPRRIIVVDL SAARLEAAVR VGADAAELPG KLIAELSEGP GADVVIEASG
EPDGFVLGTR AVRAGGHIAN IGTHGKPATL HLESLWRKNV TISTGQVDTS STPWLLELLR
NGRLPISQLV THTFPLDRMQ DAYEVFSHGA TTGALKVVLH RE
//
