ID A0A117RC77_9ACTN Unreviewed; 334 AA.
AC A0A117RC77;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha {ECO:0000313|EMBL:KUN82876.1};
GN ORFNames=AQJ64_18030 {ECO:0000313|EMBL:KUN82876.1};
OS Streptomyces griseoruber.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1943 {ECO:0000313|EMBL:KUN82876.1, ECO:0000313|Proteomes:UP000052982};
RN [1] {ECO:0000313|EMBL:KUN82876.1, ECO:0000313|Proteomes:UP000052982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40281 {ECO:0000313|EMBL:KUN82876.1,
RC ECO:0000313|Proteomes:UP000052982};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseoruber DSM 40281, type strain
RT for the species Streptomyces griseoruber.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN82876.1}.
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DR EMBL; LMWW01000027; KUN82876.1; -; Genomic_DNA.
DR RefSeq; WP_055635723.1; NZ_LIQS01000301.1.
DR AlphaFoldDB; A0A117RC77; -.
DR STRING; 1943.AQJ64_18030; -.
DR Proteomes; UP000052982; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:KUN82876.1}.
FT DOMAIN 25..324
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 334 AA; 35675 MW; 2DFC786C3B60B264 CRC64;
MAQRASTASK KSAQVSAEII KDLHERMVRI RLFETEAGKL MEAGRLPGFL HLYVGQEAVA
AGVMSALRDD DQITSTHRGH GHAVAKGVGF REMYAELYGR VTGACLGRGG SMHINDLTRG
MLGANGIVGA GVPIAVGAAF AARYKGEDSV AVTFFGDGAT NIGAFHEGAN MAAILGLPVV
FVCENNGYAE FTPQSGHMLL TDVADRAAAY GMPSVIVDGM DAVAVHRAAA EAVERARTGA
GPMMIEAKTY RYFDHQGVKG LRHPYRSDEE VAEWKSRDPI DLIEARAVAD GTATRPELDD
VWRRTRDEIA EAIAYAEASP LPDPADLLLN VYSG
//
